Document Detail


Noninvasive optical quantification of absolute blood flow, blood oxygenation, and oxygen consumption rate in exercising skeletal muscle.
MedLine Citation:
PMID:  22894482     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigates a method using novel hybrid diffuse optical spectroscopies [near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS)] to obtain continuous, noninvasive measurement of absolute blood flow (BF), blood oxygenation, and oxygen consumption rate (V̇O(2)) in exercising skeletal muscle. Healthy subjects (n=9) performed a handgrip exercise to increase BF and V̇O(2) in forearm flexor muscles, while a hybrid optical probe on the skin surface directly monitored oxy-, deoxy-, and total hemoglobin concentrations ([HbO(2)], [Hb], and THC), tissue oxygen saturation (S(t)O(2)), relative BF (rBF), and relative oxygen consumption rate (rV̇O(2)). The rBF and rV̇O(2) signals were calibrated with absolute baseline BF and V̇O(2) obtained through venous and arterial occlusions, respectively. Known problems with muscle-fiber motion artifacts in optical measurements during exercise were mitigated using a novel gating algorithm that determined muscle contraction status based on control signals from a dynamometer. Results were consistent with previous findings in the literature. This study supports the application of NIRS/DCS technology to quantitatively evaluate hemodynamic and metabolic parameters in exercising skeletal muscle and holds promise for improving diagnosis and treatment evaluation for patients suffering from diseases affecting skeletal muscle and advancing fundamental understanding of muscle and exercise physiology.
Authors:
Katelyn Gurley; Yu Shang; Guoqiang Yu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  17     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2013-01-07     Revised Date:  2013-07-16    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  075010     Citation Subset:  IM    
Affiliation:
University of Kentucky, Center for Biomedical Engineering, Lexington, Kentucky 40506, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Blood Flow Velocity / physiology
Equipment Design
Equipment Failure Analysis
Exercise / physiology*
Female
Humans
Male
Muscle Contraction / physiology*
Muscle, Skeletal / physiology*
Oximetry / instrumentation*
Oxygen / blood*
Oxygen Consumption / physiology*
Reproducibility of Results
Rheology / instrumentation
Sensitivity and Specificity
Spectroscopy, Near-Infrared / instrumentation*
Young Adult
Grant Support
ID/Acronym/Agency:
R21AG034279/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
7782-44-7/Oxygen
Comments/Corrections
Erratum In:
J Biomed Opt. 2012 Jul;17(7):079802

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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