| Noninvasive optical quantification of absolute blood flow, blood oxygenation, and oxygen consumption rate in exercising skeletal muscle. | |
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MedLine Citation:
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PMID: 22894482 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigates a method using novel hybrid diffuse optical spectroscopies [near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS)] to obtain continuous, noninvasive measurement of absolute blood flow (BF), blood oxygenation, and oxygen consumption rate (V̇O(2)) in exercising skeletal muscle. Healthy subjects (n=9) performed a handgrip exercise to increase BF and V̇O(2) in forearm flexor muscles, while a hybrid optical probe on the skin surface directly monitored oxy-, deoxy-, and total hemoglobin concentrations ([HbO(2)], [Hb], and THC), tissue oxygen saturation (S(t)O(2)), relative BF (rBF), and relative oxygen consumption rate (rV̇O(2)). The rBF and rV̇O(2) signals were calibrated with absolute baseline BF and V̇O(2) obtained through venous and arterial occlusions, respectively. Known problems with muscle-fiber motion artifacts in optical measurements during exercise were mitigated using a novel gating algorithm that determined muscle contraction status based on control signals from a dynamometer. Results were consistent with previous findings in the literature. This study supports the application of NIRS/DCS technology to quantitatively evaluate hemodynamic and metabolic parameters in exercising skeletal muscle and holds promise for improving diagnosis and treatment evaluation for patients suffering from diseases affecting skeletal muscle and advancing fundamental understanding of muscle and exercise physiology. |
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Authors:
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Katelyn Gurley; Yu Shang; Guoqiang Yu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of biomedical optics Volume: 17 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-08-16 Completed Date: 2013-01-07 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 075010 Citation Subset: IM |
Affiliation:
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University of Kentucky, Center for Biomedical Engineering, Lexington, Kentucky 40506, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Blood Flow Velocity / physiology Equipment Design Equipment Failure Analysis Exercise / physiology* Female Humans Male Muscle Contraction / physiology* Muscle, Skeletal / physiology* Oximetry / instrumentation* Oxygen / blood* Oxygen Consumption / physiology* Reproducibility of Results Rheology / instrumentation Sensitivity and Specificity Spectroscopy, Near-Infrared / instrumentation* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R21AG034279/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
Erratum In:
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J Biomed Opt. 2012 Jul;17(7):079802 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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