Document Detail

Noninvasive measurements of regional cerebral perfusion in preterm and term neonates by magnetic resonance arterial spin labeling.
MedLine Citation:
PMID:  16857776     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance arterial spin labeling (ASL) at 3 Tesla has been investigated as a quantitative technique for measuring regional cerebral perfusion (RCP) in newborn infants. RCP values were measured in 49 healthy neonates: 32 preterm infants born before 34 wk of gestation and 17 term-born neonates. Examinations were performed on unsedated infants at postmenstrual age of 39-40 wk in both groups. Due to motion, reliable data were obtained from 23 preterm and 6 term infants. Perfusion in the basal ganglia (39 and 30 mL/100 g/min for preterm and term neonates, respectively) was significantly higher (p < 0.0001) than in cortical gray matter (19 and 16 mL/100 g/min) and white matter (15 and 10 mL/100 g/min), both in preterm neonates at term-equivalent age and in term neonates. Perfusion was significantly higher (p = 0.01) in the preterm group than in the term infants, indicating that RCP may be influenced by developmental and postnatal ages. This study demonstrates, for the first time, that noninvasive ASL at 3T may be used to measure RCP in healthy unsedated preterm and term neonates. ASL is, therefore, a viable tool that will allow serial studies of RCP in high-risk neonates.
Maria J Miranda; Kern Olofsson; Karam Sidaros
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-20
Journal Detail:
Title:  Pediatric research     Volume:  60     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2007-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  359-63     Citation Subset:  IM    
Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark.
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MeSH Terms
Cerebrovascular Circulation / physiology*
Infant, Newborn
Infant, Premature
Magnetic Resonance Imaging*
Regional Blood Flow / physiology
Spin Labels*
Reg. No./Substance:
0/Spin Labels

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