Document Detail

Noninvasive measurement of oxygen tension in the optic nerve head.
MedLine Citation:
PMID:  10180515     Owner:  NLM     Status:  MEDLINE    
Understanding the pathophysiology of the optic nerve head (ONH) requires precise knowledge of the oxygenation of this tissue. Previous investigations used methods based on oxygen sensitive microelectrodes to measure the partial pressure of oxygen in the ONH tissue. These microelectrodes are inserted into the eye through the pars plana. New methods are now being developed to measure the intravascular PO2 in the ONH. They are based on the quenching of phosphorescence of a porphyrin dye by oxygen. Although these methods require an intravenous injection of this dye, the eye is left untouched. This article reviews these noninvasive methods.
C E Riva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in ophthalmology     Volume:  9     ISSN:  1040-8738     ISO Abbreviation:  Curr Opin Ophthalmol     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-22     Completed Date:  1998-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9011108     Medline TA:  Curr Opin Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  56-60     Citation Subset:  T    
Institut de Recherche en Ophtalmologie, Sion, Switzerland.
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MeSH Terms
Blood Flow Velocity
Image Processing, Computer-Assisted
Laser-Doppler Flowmetry
Luminescent Measurements
Optic Disk / blood supply,  metabolism*
Oxygen Consumption / physiology*
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