Document Detail


Noninvasive measurement of the maximum relaxation rate of inspiratory muscles in patients with neuromuscular disorders.
MedLine Citation:
PMID:  16508243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Slowing of inspiratory muscle relaxation has been used as an index for inspiratory muscle fatigue. However, maximum relaxation rate measured from oesophageal pressure traces after maximum sniff (P(oes) MRR) has limited clinical usefulness because it requires an oesophageal balloon catheter system. Objectives: It was the aim of this study to establish whether, in neuromuscular patients, maximum relaxation rate assessed from sniff nasal pressure (P(nasal) MRR) reflects oesophageal MRR and the tension-time index of the diaphragm (TT(di)). METHODS: Twenty patients with neuromuscular disease and 10 healthy subjects were studied. P(oes) and transdiaphragmatic pressure were measured while P(nasal) was recorded with a balloon advanced through the nose into the nasopharynx. Maximum P(oes), transdiaphragmatic pressure and P(nasal) were simultaneously measured while the patients performed maximal sniffs. The MRR (% pressure fall/10 ms) for each sniff, the TT(di) and the tension-time index of respiratory muscles were determined. RESULTS: Neuromuscular patients showed higher TT(di), lower P(oes) MRR and lower P(nasal) MRR than the control group. In patients with neuromuscular disease, the correlation coefficient of P(nasal) MRR and P(oes) MRR was 0.985 (p < 0.001). Regression analysis showed that P(oes) MRR = -1.101 + 1.113.P(nasal) MRR (r(2) = 0.929, standard error of the estimate = 0.208). Indeed, P(nasal) MRR was negatively correlated with TT(di) (r = -0.914, p < 0.001) and the tension-time index of respiratory muscles (r = -0.732, p < 0.001). In the neuromuscular group, the mean difference between P(nasal) MRR and P(oes) MRR was 0.286 +/- 0.217%/10 ms. CONCLUSIONS: P(nasal) MRR obtained from a maximal sniff accurately reflects P(oes) MRR and TT(di) in patients with neuromuscular disorders.
Authors:
F García-Río; O Mediano; J M Pino; V Lores; I Fernández; J L Alvarez-Sala; J Villamor
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Publication Detail:
Type:  Journal Article     Date:  2006-02-27
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  73     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  2006  
Date Detail:
Created Date:  2006-06-15     Completed Date:  2006-11-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  474-80     Citation Subset:  IM    
Affiliation:
Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain. fgr01m@jazzfree.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biopsy
Electromyography
Exhalation
Female
Forced Expiratory Volume
Humans
Inhalation
Male
Middle Aged
Muscle Relaxation*
Muscle, Skeletal / cytology,  pathology
Neuromuscular Diseases / physiopathology*
Reference Values
Respiratory Muscles / physiology,  physiopathology*
Smoking / epidemiology
Vital Capacity
Comments/Corrections
Comment In:
Respiration. 2006;73(4):412-3   [PMID:  16775413 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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