Document Detail

Noninvasive measurement of the cerebral blood flow response in human lateral geniculate nucleus with arterial spin labeling fMRI.
MedLine Citation:
PMID:  17712783     Owner:  NLM     Status:  MEDLINE    
To date, functional magnetic resonance imaging (fMRI) studies of the lateral geniculate nucleus (LGN) have primarily focused on measures of the blood oxygenation level dependent (BOLD) signal. Arterial spin labeling (ASL) is an MRI method that can provide direct measures of functional cerebral blood flow (CBF) changes. Because CBF is a well-defined physiological quantity that contributes to BOLD contrast, CBF measures can be used to improve the quantitative interpretation of fMRI studies. However, due in part to the low intrinsic signal-to-noise ratio of the ASL method, measures of functional CBF changes in the LGN are challenging and have not previously been reported. In this study, we demonstrate the feasibility of using ASL fMRI to measure the CBF response of the LGN to visual stimulation on a 3 T MRI system. The use of background suppression and physiological noise reduction techniques allowed reliable detection of LGN activation in all five subjects studied. The measured percent CBF response during activation ranged from 40 to 100%, assuming no interaction between the left and right LGN.
Kun Lu; Joanna E Perthen; Robert O Duncan; Linda M Zangwill; Thomas T Liu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Human brain mapping     Volume:  29     ISSN:  1097-0193     ISO Abbreviation:  Hum Brain Mapp     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-12-30     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9419065     Medline TA:  Hum Brain Mapp     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1207-14     Citation Subset:  IM    
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MeSH Terms
Brain Mapping / methods*
Cerebrovascular Circulation*
Geniculate Bodies / blood supply*
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods*
Grant Support
5R01EY011008-10/EY/NEI NIH HHS; R01 EY011008/EY/NEI NIH HHS; R01 EY011008-13/EY/NEI NIH HHS

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