Document Detail

Noninvasive imaging of electrophysiological substrates in post myocardial infarction.
MedLine Citation:
PMID:  20426177     Owner:  NLM     Status:  MEDLINE    
The presence of injured tissues after myocardial infarction (MI) creates substrates responsible for fatal arrhythmia; understanding of its arrhythmogenic mechanism requires investigation of the correlation of local abnormality between phenomenal electrical functions and inherent electrophysiological properties during normal sinus rhythm. This paper presents a physiological-model-constrained framework for imaging post-MI electrophysiological substrates from noninvasive body surface potential measurements. Using a priori knowledge of general cardiac electrical activity as constraints, it simultaneously reconstruct transmembrane potential dynamics and tissue excitability inside the 3D myocardium, with the central goal to localize and investigate the abnormality in these two different electrophysiological quantities. It is applied to four post-MI patients with quantitative validations by gold standards and notable improvements over existent results.
Linwei Wang; Heye Zhang; Ken C L Wong; Huafeng Liu; Pengcheng Shi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention     Volume:  12     ISSN:  -     ISO Abbreviation:  Med Image Comput Comput Assist Interv     Publication Date:  2009  
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101249582     Medline TA:  Med Image Comput Comput Assist Interv     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  732-40     Citation Subset:  IM    
Computational Biomedicine Laboratory, Rochester Institute of Technology, Rochester, New York, USA.
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MeSH Terms
Body Surface Potential Mapping / methods*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Myocardial Infarction / diagnosis*
Reproducibility of Results
Sensitivity and Specificity

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