Document Detail

Noninvasive identification of severe coronary artery disease using exercise tomographic thallium-201 imaging.
MedLine Citation:
PMID:  1615863     Owner:  NLM     Status:  MEDLINE    
The ability of exercise thallium-201 tomographic imaging to predict the presence of left main or 3-vessel coronary artery disease (CAD) was examined in 688 patients who underwent both exercise thallium-201 testing and coronary angiography. Significant differences existed for multiple variables between patients with (n = 196) and without (n = 492) severe left main or 3-vessel CAD. Logistic regression analysis identified 4 variables as independently predictive of left main or 3-vessel CAD. These variables were the magnitude of ST-segment depression with exercise, the number of visually abnormal short-axis thallium-201 segments, the presence or absence of diabetes mellitus, and the change in systolic blood pressure with exercise. Using these variables, patients were classified by nomograms into low-, intermediate- and high-probability groups. Patients at high probability (n = 205) had a 52% prevalence of 3-vessel or left main CAD, whereas those at low probability (n = 170) had only a 12% prevalence. Only 53 patients (29%) with 3-vessel or left main CAD had perfusion abnormalities in all 3 coronary territories. Clinical and exercise parameters provide important independent information in the identification of left main or 3-vessel CAD by exercise thallium-201 tomographic imaging, because thallium scintigraphy alone is suggestive of extensive CAD in few patients.
T F Christian; T D Miller; K R Bailey; R J Gibbons
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  70     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  14-20     Citation Subset:  AIM; IM    
Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
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MeSH Terms
Blood Pressure
Chi-Square Distribution
Coronary Angiography
Coronary Disease / complications,  diagnosis,  radionuclide imaging*
Diabetes Complications
Exercise Test*
Logistic Models
Middle Aged
Predictive Value of Tests
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed*
Reg. No./Substance:
0/Thallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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