| Noninvasive fetal genotyping of human platelet antigen-1a. | |
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MedLine Citation:
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PMID: 21749627 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Please cite this paper as: Scheffer P, Ait Soussan A, Verhagen O, Page-Christiaens G, Oepkes D, de Haas M, van der Schoot C. Noninvasive fetal genotyping of human platelet antigen-1a. BJOG 2011; DOI: 10.1111/j.1471-0528.2011.03039.x. We describe a reliable noninvasive fetal human platelet antigen (HPA)-1a genotyping assay on a real-time polymerase chain reaction (PCR) platform using cell-free fetal DNA isolated from maternal blood. Nonspecific amplification of maternal cell-free DNA is overcome by pre-PCR digestion of the cell-free DNA with the Msp1 restriction enzyme. Noninvasive fetal HPA-1a genotyping offers a safe method for alloimmunised pregnant women to determine whether their fetus is at risk of fetal or neonatal alloimmune thrombocytopenia (FNAIT) and whether interventions to prevent intracranial haemorrhage are required. The availability of this test is relevant to the ongoing debate on screening pregnancies for HPA-1a-mediated FNAIT. |
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Authors:
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Pg Scheffer; A Ait Soussan; Ojhm Verhagen; Gcml Page-Christiaens; D Oepkes; M de Haas; Ce van der Schoot |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-12 |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: - ISSN: 1471-0528 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG. |
Affiliation:
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Department of Experimental Immunohaematology, Sanquin Research Amsterdam and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands Division of Perinatology and Gynaecology, University Medical Centre Utrecht, Utrecht, the Netherlands Department of Obstetrics, Leiden University Medical Centre, Leiden, the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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