| Noninvasive fetal RhD genotyping from maternal blood. | |
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MedLine Citation:
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PMID: 20370586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rhesus (Rh) D blood group incompatibility between a pregnant woman and the fetus can occasionally cause maternal alloimmunization and hemolytic disease of the fetus and of the newborn in subsequent pregnancies. RHD genotyping of fetuses carried by RhD-negative women using fetal DNA obtained invasively through amniocentesis or chorionic villus sampling is an aid to the clinical management of these cases. Technological advances allow for accurate prediction of fetal RHD genotype using cell-free fetal DNA from maternal blood, thus overcoming the invasive procedures. Presently, many laboratories worldwide provide the test as a routine service for immunized women. Mass application of RhD noninvasive prenatal diagnosis for all fetuses carried by RhD-negative women is highly desirable so that unnecessary anti-D administration is avoided. |
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Authors:
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Aggeliki Kolialexi; Georgia Tounta; Ariadni Mavrou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of molecular diagnostics Volume: 10 ISSN: 1744-8352 ISO Abbreviation: Expert Rev. Mol. Diagn. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120777 Medline TA: Expert Rev Mol Diagn Country: England |
Other Details:
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Languages: eng Pagination: 285-96 Citation Subset: IM |
Affiliation:
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Department of Medical Genetics, Athens University School of Medicine, Thivon & Levadias, Athens, Greece. akolial@med.uoa.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diagnostic Errors Female Fetus / immunology, physiology* Genotype* Humans Infant, Newborn / blood*, immunology Polymerase Chain Reaction / methods, standards Polymorphism, Genetic Pregnancy / blood*, immunology Prenatal Diagnosis / methods* Rh-Hr Blood-Group System / genetics*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Rh-Hr Blood-Group System; 0/Rho(D) antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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