Document Detail


Noninvasive fetal RhD genotyping from maternal blood.
MedLine Citation:
PMID:  20370586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rhesus (Rh) D blood group incompatibility between a pregnant woman and the fetus can occasionally cause maternal alloimmunization and hemolytic disease of the fetus and of the newborn in subsequent pregnancies. RHD genotyping of fetuses carried by RhD-negative women using fetal DNA obtained invasively through amniocentesis or chorionic villus sampling is an aid to the clinical management of these cases. Technological advances allow for accurate prediction of fetal RHD genotype using cell-free fetal DNA from maternal blood, thus overcoming the invasive procedures. Presently, many laboratories worldwide provide the test as a routine service for immunized women. Mass application of RhD noninvasive prenatal diagnosis for all fetuses carried by RhD-negative women is highly desirable so that unnecessary anti-D administration is avoided.
Authors:
Aggeliki Kolialexi; Georgia Tounta; Ariadni Mavrou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of molecular diagnostics     Volume:  10     ISSN:  1744-8352     ISO Abbreviation:  Expert Rev. Mol. Diagn.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120777     Medline TA:  Expert Rev Mol Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  285-96     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics, Athens University School of Medicine, Thivon & Levadias, Athens, Greece. akolial@med.uoa.gr
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MeSH Terms
Descriptor/Qualifier:
Diagnostic Errors
Female
Fetus / immunology,  physiology*
Genotype*
Humans
Infant, Newborn / blood*,  immunology
Polymerase Chain Reaction / methods,  standards
Polymorphism, Genetic
Pregnancy / blood*,  immunology
Prenatal Diagnosis / methods*
Rh-Hr Blood-Group System / genetics*,  immunology
Chemical
Reg. No./Substance:
0/Rh-Hr Blood-Group System; 0/Rho(D) antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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