Document Detail

Noninvasive evaluation of splanchnic tissue oxygenation using near-infrared spectroscopy in preterm neonates.
MedLine Citation:
PMID:  20828232     Owner:  NLM     Status:  In-Data-Review    
Background. Diagnosis of necrotizing enterocolitis (NEC) in preterm neonates is challenging. We hypothesized that regional splanchnic oxygen saturation (rsSO(2)) measured by near-infrared spectroscopy (NIRS) is a biomarker for mesenteric perfusion. Objective. To evaluate feasibility and safety of continuous rsSO(2) monitoring in preterm infants in the first 14 days of life. Methods. Preterm neonates ≤30 weeks' gestation had a NIRS sensor placed in the left paraumbilical region within 48 h of birth. rsSO(2) was recorded every 30 s. Clinical data including pulse oximetry (SaO(2)) were recorded. Fractional tissue oxygen extraction (FTOE) was computed as follows: (SaO(2) - rsSO(2)) × 100/SaO(2). Results. Of 21 infants enrolled, 2 were excluded because of skin breakdown and missing data. Daily mean rsSO(2) values decreased over the first 9 days (p < 0.0001) followed by an increase from day 10 (D10) to D14 (p = 0.0061). rsSO(2) was lower and FTOE was higher in infants with feeding intolerance compared to those without feeding intolerance (p = 0.0043). rsSO(2) accounted for ≥99.5% of the variance in FTOE. Two neonates with NEC had persistently low rsSO(2) with loss of variability preceded or followed by very high rsSO(2). Conclusions. We have reported feasibility, safety and ranges for rsSO(2) for a small number of preterm infants in the first 2 weeks of life.
Josef Cortez; Meenakshi Gupta; Arun Amaram; Janet Pizzino; Megha Sawhney; Beena G Sood
Publication Detail:
Type:  Journal Article     Date:  2010-09-09
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  24     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  574-82     Citation Subset:  IM    
Division of Neonatal-Perinatal Medicine,Wayne State University and Children's Hospital of Michigan, Detroit, Michigan 48201, USA.
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