Document Detail


Noninvasive evaluation of portal hypertension: emerging tools and techniques.
MedLine Citation:
PMID:  22720166     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Portal hypertension is the main cause of complications in patients with cirrhosis. However, evaluating the development and progression of portal hypertension represents a challenge for clinicians. There has been considerable focus on the potential role of noninvasive markers of portal hypertension that could be used to stratify patients with respect to the stage of portal hypertension and to monitor disease progression or treatment response in a longitudinal manner without having to undertake repeated invasive assessment. The pathogenesis of portal hypertension is increasingly understood and emerging knowledge of the vascular processes that underpin portal hypertension has paved the way for exploring novel biomarkers of vascular injury, angiogenesis, and endothelial dysfunction. In this paper we focus on the pathogenesis of portal hypertension and potential non-invasive biomarkers with particular emphasis on serum analytes.
Authors:
V K Snowdon; N Guha; J A Fallowfield
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Publication Detail:
Type:  Journal Article     Date:  2012-06-07
Journal Detail:
Title:  International journal of hepatology     Volume:  2012     ISSN:  2090-3456     ISO Abbreviation:  Int J Hepatol     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-21     Completed Date:  2012-08-23     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101564967     Medline TA:  Int J Hepatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  691089     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
G0901697//Medical Research Council
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