Document Detail


Noninvasive evaluation of indecainide for serious ventricular tachyarrhythmia.
MedLine Citation:
PMID:  2451415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Indecainide, a new class 1C agent, was administered to 16 patients with a history of ventricular fibrillation or ventricular tachycardia. Evaluation of drug effect consisted of acute testing with 125 mg followed by a period of maintenance therapy. Efficacy, as evaluated with both ambulatory monitoring and exercise testing, was defined as total elimination of runs of ventricular tachycardia, greater than 90% reduction in couplets and greater than 50% decrease in ventricular premature complex. During acute drug testing 9 of the 16 patients responded to the drug. Four patients did not receive maintenance therapy with indecainide, because of toxic side effects. Of the remaining 12 patients, 7 responded to indecainide based on monitoring, 5 responded judged by exercise testing and 4 when both monitoring and exercise testing were considered. There was no correlation between dose, blood level of drug and effect on arrhythmia. In this small group acute drug testing did not appear to predict the response to the drug during maintenance therapy. Neurologic side effects were reported by 5 patients. Aggravation of arrhythmia occurred in 5 patients, 3 of whom had this complication during acute drug testing and 2 during maintenance therapy. Left ventricular ejection fraction, measured before and during therapy, decreased from an average of 43% to 35% (p less than 0.005). A reduction was observed irrespective of baseline left ventricular function. Indecainide is an effective antiarrhythmic agent in a small number of highly selected patients with serious ventricular arrhythmia, but potentially serious side effects limit its usefulness.
Authors:
P J Podrid; S Hohnloser; B Lown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  61     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-04-22     Completed Date:  1988-04-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  764-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Arrhythmia Agents / adverse effects,  therapeutic use*
Cardiac Complexes, Premature / drug therapy
Electrocardiography
Exercise Test
Female
Fluorenes / adverse effects,  therapeutic use*
Humans
Male
Middle Aged
Monitoring, Physiologic
Nervous System Diseases / chemically induced
Stroke Volume / drug effects
Tachycardia / drug therapy*
Ventricular Fibrillation / drug therapy*
Grant Support
ID/Acronym/Agency:
HL-07776/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Fluorenes; 74517-78-5/indecainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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