| Noninvasive evaluation of endolymphatic space in healthy volunteers using magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 21070090 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Conclusions: A new method for noninvasive standard evaluation of normal endolymphatic space and endolymphatic hydrops using magnetic resonance imaging (MRI) is indicated. Objective: To standardize the evaluation of endolymphatic space in the cochlea and the vestibule in healthy volunteers by applying noninvasive intratympanic gadolinium (Gd) perfusion through the eustachian tube and three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI). Methods: This was a prospective study. 3D-FLAIR MRI was performed with a 3 Tesla (3 T) unit 24 h after intratympanic administration of Gd through the eustachian tube in 20 healthy volunteers. Pure tone test and tympanometry were performed 24 h before Gd was administered, and 24 h and 1 month after Gd administration. Results: Gd was present in the perilymph of the inner ear, which clearly displayed the endolymphatic space on 3D-FLAIR MRI with a visible borderline between the perilymph and the endolymph. In healthy volunteers, the normal value for the endolymphatic space in the cochlea ranged between 9% and 28%, and that in the vestibule was between 14% and 40%. No significant changes in pure tone test and tympanometry were noted. |
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Authors:
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Fang Liu; Weining Huang; Zhenchang Wang; Qinghua Chen; Xuhui Liu; Shuling Li; Shijun Wang |
Publication Detail:
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Type: Journal Article Date: 2010-11-11 |
Journal Detail:
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Title: Acta oto-laryngologica Volume: 131 ISSN: 1651-2251 ISO Abbreviation: Acta Otolaryngol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: England |
Other Details:
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Languages: eng Pagination: 247-57 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Beijing Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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