Document Detail

Noninvasive estimation of cerebral perfusion pressure with transcranial Doppler ultrasonography in traumatic brain injury.
MedLine Citation:
PMID:  22843455     Owner:  NLM     Status:  MEDLINE    
AIM: In traumatic brain injury (TBI) patients, to overcome the secondary insults, cerebral perfusion pressure (CPP) oriented therapy is recommended. The study is assigned to estimate CPP values with middle cerebral artery (MCA) flow velocities measured noninvasively using transcranial Doppler ultrasonography (TCD).
MATERIAL AND METHODS: Forty-seven TBI patients were studied. Intracranial pressure (ICP), mean arterial pressure (MAP) and MCA flow velocities of the patients were monitored. Invasive CPP was calculated as the difference between MAP and ICP. The formula : 'MAP x FVd/FVm +14' was used to estimate CPP noninvasively. Correlation of the noninvasive and invasive values were analysed.
RESULTS: The mean values of noninvasive CPP and invasive CPP were 66.10 ± 10.55 mmHg and 65.40 ± 10.03 mmHg respectively. The correlation between noninvasive and invasive CPP measurements was strongly significant (p < 0.001) with a correlation coefficient of r = 0.920.
CONCLUSION: With ICP monitoring systems, CPP is calculated and the therapy is guided according to these values. As it is recognized that brain perfusion can be assessed with TCD waveforms, noninvasive CPP estimation with MCA flow velocities may help to observe the trends in CPP values.
Melek Gura; Gokalp Silav; Nejat Isik; Ilhan Elmaci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Turkish neurosurgery     Volume:  22     ISSN:  1019-5149     ISO Abbreviation:  Turk Neurosurg     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-12-07     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9423821     Medline TA:  Turk Neurosurg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  411-5     Citation Subset:  IM    
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MeSH Terms
Arterial Pressure
Blood Pressure / physiology*
Brain Hemorrhage, Traumatic / physiopathology,  ultrasonography
Brain Injuries / physiopathology*,  ultrasonography*
Cerebrovascular Circulation / physiology*
Monitoring, Physiologic
Prospective Studies
Tomography, X-Ray Computed
Ultrasonography, Doppler, Transcranial / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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