Document Detail


Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia.
MedLine Citation:
PMID:  15034569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over 7 million people worldwide die annually from erratic heart rhythms (cardiac arrhythmias), and many more are disabled. Yet there is no imaging modality to identify patients at risk, provide accurate diagnosis and guide therapy. Standard diagnostic techniques such as the electrocardiogram (ECG) provide only low-resolution projections of cardiac electrical activity on the body surface. Here we demonstrate the successful application in humans of a new imaging modality called electrocardiographic imaging (ECGI), which noninvasively images cardiac electrical activity in the heart. In ECGI, a multielectrode vest records 224 body-surface electrocardiograms; electrical potentials, electrograms and isochrones are then reconstructed on the heart's surface using geometrical information from computed tomography (CT) and a mathematical algorithm. We provide examples of ECGI application during atrial and ventricular activation and ventricular repolarization in (i) normal heart (ii) heart with a conduction disorder (right bundle branch block) (iii) focal activation initiated by right or left ventricular pacing, and (iv) atrial flutter.
Authors:
Charulatha Ramanathan; Raja N Ghanem; Ping Jia; Kyungmoo Ryu; Yoram Rudy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-03-14
Journal Detail:
Title:  Nature medicine     Volume:  10     ISSN:  1078-8956     ISO Abbreviation:  Nat. Med.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-01     Completed Date:  2004-06-08     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9502015     Medline TA:  Nat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / physiopathology*
Electrocardiography / methods*
Heart / physiopathology*
Heart Atria / physiopathology
Heart Ventricles / physiopathology
Humans
Grant Support
ID/Acronym/Agency:
R01-HL-49054/HL/NHLBI NIH HHS; R37 HL033343/HL/NHLBI NIH HHS; R37 HL033343-20/HL/NHLBI NIH HHS; R37-HL-33343/HL/NHLBI NIH HHS
Comments/Corrections

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