| Noninvasive electrocardiographic imaging of arrhythmogenesis: insights from modeling and human studies. | |
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MedLine Citation:
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PMID: 17993317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sudden cardiac death remains the leading cause of death, claiming more than 1000 lives per day in the United States alone. Noninvasive means to diagnose rhythm disorders of the heart have relied heavily on the 12-lead electrocardiogram and, to a lesser extent, on higher-resolution body-surface mapping. These lack sensitivity and specificity due to the smoothing effect of the torso volume conductor. In contrast, noninvasive electrocardiographic imaging (ECGI) reconstructs potentials, electrograms, and activation sequences directly on the heart surface from body-surface electrocardiograms and has been applied in animal as well as clinical studies. This presentation summarizes the application of ECGI for imaging epicardial arrhythmogenic substrates and associated properties, in particular, dispersion of myocardial repolarization, fractionated electrograms, and heterogeneous multipolar potential distributions. METHODS: Electrocardiographic imaging was evaluated in a canine model of temperature-induced dispersion of myocardial repolarization through localized warming and cooling and in 3 patients with preserved left ventricular ejection fraction (>or=50%) undergoing open heart surgery. Noninvasively reconstructed epicardial potentials, electrograms (and derived measures), as well as activation sequences were compared with their measured counterparts. RESULTS: Epicardial measures of dispersion of repolarization (activation recovery intervals [ARIs] and QRST integrals) accurately reflected the underlying repolarization properties: prolonged ARIs and increased QRST (warming), shortened ARIs and decreased QRST (cooling), and gradients of adjacent prolonged and shortened ARIs (increased and decreased QRST) during simultaneous warming and cooling. In open-heart surgery patients, ECGI reflected the underlying arrhythmogenic substrate by noninvasively reconstructing fractionated electrograms (cross-correlation with measured electrograms = 0.72 +/- 0.25), regions of heterogeneous multipolar potential distributions, and areas of slow conduction. CONCLUSION: These studies demonstrate that ECGI can capture and localize noninvasively important electrophysiologic properties of the heart. Its clinical significance lies in mapping arrhythmogenic substrates, evaluation and guidance of therapy, and risk stratification. |
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Authors:
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Raja N Ghanem |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of electrocardiology Volume: 40 ISSN: 1532-8430 ISO Abbreviation: J Electrocardiol Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2007-11-12 Completed Date: 2008-01-07 Revised Date: 2011-01-10 |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: S169-73 Citation Subset: IM |
Affiliation:
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Medtronic Cardiac Rhythm Disease Management, Minneapolis, MN, USA. raja.ghanem@medtronic.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / diagnosis* Body Surface Potential Mapping / methods* Computer Simulation Diagnosis, Computer-Assisted / methods* Diagnostic Imaging / methods* Dogs Humans Models, Cardiovascular* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL038408-13/HL/NHLBI NIH HHS; R01 HL049054-16/HL/NHLBI NIH HHS; R01-HL-38408/HL/NHLBI NIH HHS; R01-HL-49054/HL/NHLBI NIH HHS; R37 HL033343-23/HL/NHLBI NIH HHS; R37-HL-33343/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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