Document Detail

Noninvasive diffusive optical imaging of the auditory response to birdsong in the zebra finch.
MedLine Citation:
PMID:  23322445     Owner:  NLM     Status:  Publisher    
Songbirds communicate by learned vocalizations with concomitant changes in neurophysiological and genomic activities in discrete parts of the brain. Here, we tested a novel implementation of diffusive optical imaging (also known as diffuse optical imaging, DOI) for monitoring brain physiology associated with vocal signal perception. DOI noninvasively measures brain activity using red and near-infrared light delivered through optic fibers (optodes) resting on the scalp. DOI does not harm subjects, so it raises the possibility of repeatedly measuring brain activity and the effects of accumulated experience in the same subject over an entire life span, all while leaving tissue intact for further study. We developed a custom-made apparatus for interfacing optodes to the zebra finch (Taeniopygia guttata) head using 3D modeling software and rapid prototyping technology, and applied it to record responses to presentations of birdsong in isoflurane-anesthetized zebra finches. We discovered a subtle but significant difference between the hemoglobin spectra of zebra finches and mammals which has a major impact in how hemodynamic responses are interpreted in the zebra finch. Our measured responses to birdsong playback were robust, highly repeatable, and readily observed in single trials. Responses were complex in shape and closely paralleled responses described in mammals. They were localized to the caudal medial portion of the brain, consistent with response localization from prior gene expression, electrophysiological, and functional magnetic resonance imaging studies. These results define an approach for collecting neurophysiological data from songbirds that should be applicable to diverse species and adaptable for studies in awake behaving animals.
James V Lee; Edward L Maclin; Kathy A Low; Gabriele Gratton; Monica Fabiani; David F Clayton
Related Documents :
23902645 - Brain imaging and human nutrition: which measures to use in intervention studies?
22222305 - Evaluation of neonatal regional cerebral perfusion using power doppler and the index fr...
3892405 - Fluctuations of light absorption of healthy papillae repeatedly photographed over a lon...
24055705 - Detecting resting-state brain activity by spontaneous cerebral blood volume fluctuation...
12483025 - Novel noninvasive sensitive determination of tear volume changes in normal cats.
6397705 - The use of 99tcm-dtpa aerosol ventilation scintigraphy in the diagnosis of pulmonary em...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology     Volume:  -     ISSN:  1432-1351     ISO Abbreviation:  J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101141792     Medline TA:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Beckman Institute, University of Illinois at Urbana-Champaign, Champaign, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Isolation of a novel strain of Planomicrobium chinense from diesel contaminated soil of tropical env...
Next Document:  Do frog-eating bats perceptually bind the complex components of frog calls?