Document Detail


Noninvasive diagnosis of acute rejection of renal allografts.
MedLine Citation:
PMID:  19935064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Acute rejection is an immune process that begins with the recognition of the allograft as nonself and ends in graft destruction. Histological features of the allograft biopsy are currently used for the differential diagnosis of allograft dysfunction. In view of the safety and the opportunity for repetitive sampling, development of noninvasive biomarkers of allograft status is an important objective in transplantation. Herein, we review some of the progress towards the development of noninvasive biomarkers of human allograft status.
RECENT FINDINGS: Urinary cell and peripheral blood cell mRNA profiles have been associated with acute rejection of human renal allografts. Emerging data support the idea that development of noninvasive biomarkers predictive of antibody-mediated rejection is feasible. The demonstration that intragraft microRNA expression predicts renal allograft status suggests that noninvasively ascertained microRNA profiles may be of value.
SUMMARY: We are pleased with the progress to date, and anticipate clinical trials investigating the hypotheses that noninvasively ascertained mRNA profiles will minimize the need for invasive biopsy procedures, predict the development of acute rejection and chronic allograft nephropathy, facilitate preemptive therapy capable of preserving graft function, and facilitate personalization of immunosuppressive therapy for the allograft recipient.
Authors:
Choli Hartono; Thangamani Muthukumar; Manikkam Suthanthiran
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in organ transplantation     Volume:  15     ISSN:  1531-7013     ISO Abbreviation:  Curr Opin Organ Transplant     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-14     Completed Date:  2010-03-11     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9717388     Medline TA:  Curr Opin Organ Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Affiliation:
Division of Nephrology and Hypertension, Departments of Medicine and Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York 10065, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Biological Markers / blood,  urine
Biopsy
Genetic Markers*
Genetic Testing*
Graft Rejection / diagnosis*,  genetics,  immunology
Graft Survival / genetics*
Humans
Kidney Transplantation / adverse effects*
MicroRNAs* / blood,  urine
Predictive Value of Tests
RNA, Messenger* / blood,  urine
Reproducibility of Results
Transplantation, Homologous
Treatment Outcome
Grant Support
ID/Acronym/Agency:
R01 AI051652-05/AI/NIAID NIH HHS; R01 AI072790/AI/NIAID NIH HHS; R01 AI072790-03/AI/NIAID NIH HHS; R01 AI072790-05/AI/NIAID NIH HHS; R01 AI60706/AI/NIAID NIH HHS; R37 AI051652/AI/NIAID NIH HHS; R37 AI051652-06/AI/NIAID NIH HHS; R37 AI051652-08/AI/NIAID NIH HHS; R37 AI51652/AI/NIAID NIH HHS; UL1-RR024996/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Genetic Markers; 0/MicroRNAs; 0/RNA, Messenger
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