Document Detail


Noninvasive continuous functional near-infrared spectroscopy combined with electroencephalography recording of frontal lobe seizures.
MedLine Citation:
PMID:  23157511     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Purpose:  To investigate spatial and metabolic changes associated with frontal lobe seizures. Methods:  Functional near-infrared spectroscopy combined with electroencephalography (EEG-fNIRS) recordings of patients with confirmed nonlesional refractory frontal lobe epilepsy (FLE). Key Findings:  Eighteen seizures from nine patients (seven male, mean age 27 years, range 13-46 years) with drug-refractory FLE were captured during EEG-fNIRS recordings. All seizures were coupled with significant hemodynamic variations that were greater with electroclinical than with electrical seizures. fNIRS helped in the identification of seizures in three patients with more subtle ictal EEG abnormalities. Hemodynamic changes consisted of local increases in oxygenated (HbO) and total hemoglobin (HbT) but heterogeneous deoxygenated hemoglobin (HbR) behavior. Furthermore, rapid hemodynamic alterations were observed in the homologous contralateral region, even in the absence of obvious propagated epileptic activity. The extent of HbO activation adequately lateralized the epileptogenic side in the majority of patients. Significance:  EEG-fNIRS reveals complex spatial and metabolic changes during focal frontal lobe seizures. Further characterization of these changes could improve seizure detection, localization, and understanding of the impact of focal seizures.
Authors:
Dang Khoa Nguyen; Julie Tremblay; Philippe Pouliot; Phetsamone Vannasing; Olivia Florea; Lionel Carmant; Franco Lepore; Mohamad Sawan; Frédéric Lesage; Maryse Lassonde
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Epilepsia     Volume:  -     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International League Against Epilepsy.
Affiliation:
Neurology Division, University of Montreal Health Center (CHUM) Notre-Dame Hospital, Montreal, Quebec, Canada Saint-Justine Hospital Research Center, Montreal, Quebec, Canada École polytechnique, University of Montreal, Montreal, Quebec, Canada Centre de recherche en neuropsychologie et cognition, University of Montreal, Montreal, Quebec, Canada.
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