Document Detail

Noninvasive cardiac output measurements in patients with pulmonary hypertension.
MedLine Citation:
PMID:  23100501     Owner:  NLM     Status:  Publisher    
Pulmonary hypertension (PH) is characterized by a progressive decline in cardiac output (CO) and right heart failure. NICOM(®) is a bioreactance-based technology that has been broadly validated, but its specific application in right heart failure and PH is unknown.Cardiac catheterization was performed in 50 consecutive patients with PH. CO measurements were performed using three different methods (thermodilution(TD), Fick, and NICOM) at baseline and after vasodilator challenge. We compared the precision (coefficient of variation) and accuracy of NICOM compared to TD and Fick.The mean CO (L·min(-1)) at baseline as measured by the three methods was 4.73±1.15 (NICOM), 5.69±1.74 (TD), and 4.84±1.39 (Fick). CO measured by NICOM was more precise than by TD (3.5±0.3% vs. 9.6±6.1%, p<0.001). Bland-Altman analyses comparing NICOM to TD and Fick revealed bias and 95% limits of agreement that were comparable to those comparing Fick to TD. All three CO methods detected an increase in CO in response to vasodilator challenge.CO measured via NICOM is precise and reliably measures CO at rest and changes in CO with vasodilator challenge in patients with PH. NICOM may allow for the noninvasive hemodynamic assessment of patients with PH and their response to therapy.
Jonathan D Rich; Stephen L Archer; Stuart Rich
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-25
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Section of Cardiology, Chicago, IL.
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