| Noninvasive capnometry for end-tidal carbon dioxide monitoring via nasal cannula in nonintubated neonates. | |
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MedLine Citation:
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PMID: 21146797 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Arterial blood gas analysis is the gold standard for assessing the adequacy of ventilation. However, arterial blood sampling may be associated with serious complications in neonates. The aim of the study was to utilize the side-stream capnometry measurement of end-tidal carbon dioxide (PetCO₂) via nasal cannula circuits and to verify the reliability of PetCO₂ in reflecting the arterial blood carbon dioxide(PaCO₂) level in nonintubated neonates. METHODS: A retrospective medical record review analysis was performed in nonintubated neonates admitted to the neonatal ward in a medical center. Simultaneous arterial PaCO₂ and PetCO₂ levels were evaluated. PaCO₂ and PetCO₂ levels were compared by paired t test and were correlated using Pearson's correlation. The PetCO₂ bias was defined as the difference between PaCO₂ and PetCO₂, and was assessed by Bland-Altman plot analysis. RESULTS: A total of 34 neonates were recruited, and data of 54 pairs of PaCO₂ and PetCO₂ levels were available for comparison. The average (mean ± SD) gestational age was 32.5 ± 4.2 weeks, and the average birth weight was 1881 ± 1077 g. There was a good correlation between PetCO₂ and PaCO₂ levels among all paired samples (r = 0.809, p < 0.001). When the data were divided into those with respiratory disease (n = 34) and those without (n = 20), significant correlation between PetCO₂ and PaCO₂ levels were both noted in the former group (r = 0.823, p < 0.001) and the latter group (r = 0.770, p < 0.001). The overall average mean value of PetCO₂ was lower than that of PaCO₂ (39.4 ± 8.8 mmHg vs. 41.3 ± 9.2 mmHg, p = 0.014). The difference between PetCO₂ and PaCO₂ levels was significant only among those with respiratory disease (38.8 ± 9.8 mmHg vs. 41.2 ± 10.3 mmHg, p = 0.027), but not among those without (40.5 ± 7.0 mmHg vs. 41.6 ± 7.2 mmHg, p = 0.289). CONCLUSIONS: End-tidal CO₂ measurement by side-stream capnometry through nasal cannula could provide an accurate and noninvasive estimate of PaCO₂ levels in nonintubated neonates. |
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Authors:
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Chih-Che Tai; Frank Leigh Lu; Pau-Chung Chen; Suh-Fang Jeng; Hung-Chieh Chou; Chien-Yi Chen; Po-Nien Tsao; Wu-Shiun Hsieh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics and neonatology Volume: 51 ISSN: 1875-9572 ISO Abbreviation: Pediatr Neonatol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101484755 Medline TA: Pediatr Neonatol Country: Singapore |
Other Details:
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Languages: eng Pagination: 330-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung-Shan South Road, Taipei, Taiwan. |
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Comment In:
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Pediatr Neonatol. 2010 Dec;51(6):309-10
[PMID:
21146793
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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