Document Detail


Noninvasive assessment of myocardial stunning from short-term coronary occlusion using tagged magnetic resonance imaging.
MedLine Citation:
PMID:  11545128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brief myocardial ischemia of less than 20 min duration, followed by reperfusion, is known to cause transient contractile dysfunction, often termed myocardial stunning. Tagged magnetic resonance imaging offers a noninvasive method that can be used to quantify this regional mechanical dysfunction in stunned myocardium. To this end, a closed-chest canine model of myocardial stunning was created by short-term (approximately 20-min) coronary occlusion, via inflation of an angioplasty balloon placed fluoroscopically in the left anterior descending (LAD) coronary, followed by reperfusion. Changes in myocardial strain before occlusion, during occlusion, and at 15 and 30 min after reperfusion were determined using repeated-measures analysis of variance. After instrumentation but before coronary occlusion, global reductions in myocardial strain were observed relative to animals that did not undergo coronary catheterization procedures. Declines of 46% and 49% in regional myocardial blood flow in the LAD and left circumflex bed, respectively, from preinstrumentation levels occurred due to coronary angiography and placement of a deflated angioplasty balloon in the LAD for 1 hr. During LAD occlusion, maximum myocardial shortening was significantly reduced in the anterior and anteroseptal regions of the left ventricular apex (i.e., ischemic region) but returned to baseline values by 30 min after reperfusion. No augmentation of myocardial function was observed in the nonischemic regions during occlusion or reperfusion. Thus, this noninvasive technique to evaluate myocardial ischemia demonstrated a graded response in myocardial function to ischemia and persistent regional dysfunction or "myocardial stunning" after short-term coronary occlusion.
Authors:
D L Kraitchman; H B Hillenbrand; I Oznur; J A Lima; E R McVeigh; E A Zerhouni; D A Bluemke
Related Documents :
9990528 - Effects of a metalloproteinase that truncates p-selectin glycoprotein ligand on neutrop...
2831348 - Reduction of experimental canine myocardial infarct size with prostaglandin e1: inhibit...
16044078 - Nicorandil attenuates nf-kappab activation, adhesion molecule expression, and cytokine ...
10840018 - Time course and mechanism of myocardial catecholamine release during transient ischemia...
23960198 - Teaching neuroimages: sciatic neuropathy after heroin abuse.
10390018 - Coherence between body surface ecg leads and intracardiac signals increases during the ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance     Volume:  2     ISSN:  1097-6647     ISO Abbreviation:  J Cardiovasc Magn Reson     Publication Date:  2000  
Date Detail:
Created Date:  2001-09-06     Completed Date:  2001-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815616     Medline TA:  J Cardiovasc Magn Reson     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-36     Citation Subset:  IM    
Affiliation:
Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Angioplasty, Balloon
Animals
Coronary Vessels / physiopathology
Disease Models, Animal
Dogs
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Magnetic Resonance Imaging / methods*
Microspheres
Myocardial Contraction / physiology
Myocardial Ischemia / physiopathology
Myocardial Stunning / physiopathology*
Radioisotopes / diagnostic use
Ventricular Dysfunction, Left / physiopathology*
Grant Support
ID/Acronym/Agency:
R01-HL45090-08/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reduction in sample size for studies of remodeling in heart failure by the use of cardiovascular mag...
Next Document:  Treatment of claustrophobia for cardiovascular magnetic resonance: use and effectiveness of mild sed...