Document Detail

Noninvasive assessment of mitral inertness [correction of inertance]: clinical results with numerical model validation.
MedLine Citation:
PMID:  14640109     Owner:  NASA     Status:  MEDLINE    
Inertial forces (Mdv/dt) are a significant component of transmitral flow, but cannot be measured with Doppler echo. We validated a method of estimating Mdv/dt. Ten patients had a dual sensor transmitral (TM) catheter placed during cardiac surgery. Doppler and 2D echo was performed while acquiring LA and LV pressures. Mdv/dt was determined from the Bernoulli equation using Doppler velocities and TM gradients. Results were compared with numerical modeling. TM gradients (range: 1.04-14.24 mmHg) consisted of 74.0 +/- 11.0% inertial forcers (range: 0.6-12.9 mmHg). Multivariate analysis predicted Mdv/dt = -4.171(S/D (RATIO)) + 0.063(LAvolume-max) + 5. Using this equation, a strong relationship was obtained for the clinical dataset (y=0.98x - 0.045, r=0.90) and the results of numerical modeling (y=0.96x - 0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography.
M S Firstenberg; N L Greenberg; N G Smedira; P M McCarthy; M J Garcia; J D Thomas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Validation Studies    
Journal Detail:
Title:  Computers in cardiology     Volume:  28     ISSN:  0276-6574     ISO Abbreviation:  Comput Cardiol     Publication Date:  2001  
Date Detail:
Created Date:  2003-11-25     Completed Date:  2004-02-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7504430     Medline TA:  Comput Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  613-6     Citation Subset:  S    
The Cleveland Clinic Foundation, Cleveland, USA.
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MeSH Terms
Cardiopulmonary Bypass
Echocardiography, Doppler / methods,  statistics & numerical data*
Linear Models
Middle Aged
Mitral Valve / physiopathology*,  ultrasonography*
Models, Cardiovascular*
Multivariate Analysis
Reproducibility of Results
Ventricular Dysfunction, Left / physiopathology,  ultrasonography*
Ventricular Pressure
Grant Support
J D Thomas / Cleveland Clinic Found, OH

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