Document Detail


Noninvasive assessment of impaired endothelial function in psoriasis.
MedLine Citation:
PMID:  19529939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objectives of this study are noninvasive assessment of endothelial dysfunction (ED) and diagnosing the possible early vascular development of atherosclerosis in psoriasis disease (PD). Twenty-eight PD patients (study group) without any obstructive vascular involvement were compared with 28 healthy controls (control group) in terms of ED utilizing endothelium-dependent dilation as well as endothelium-independent dilation, which was assessed by measuring changes in brachial artery diameter following sublingual glyceryl trinitrate (400 microg Nitrolingual spray). All patients underwent a complete transthoracic echocardiographic and tissue Doppler study. A standard form was utilized for the documentation of the presence or absence of the known risk factors for atherosclerotic vascular disease. Statistical analysis was performed by utilizing SPSS version 11. There was no difference between patients and controls in terms of echocardiographic and tissue Doppler parameters as well as baseline brachial artery diameters. Flow-mediated dilation showed 37% impairment in study group compared with control (p < 0.05). Endothelium-independent NTG dilatation did not differ in both groups. Noninvasive methods such as ultrasonography, saving time and cost-effective, can be utilized for following outpatient PD patients for the risk of ED, which may preclude to atherosclerosis.
Authors:
Rifat Eralp Ulusoy; Ozlem Karabudak; Mehmet Yokusoglu; Fethi Kilicaslan; Ata Kirilmaz; Bekir Sitki Cebeci
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Publication Detail:
Type:  Journal Article     Date:  2009-06-16
Journal Detail:
Title:  Rheumatology international     Volume:  30     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  479-83     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Gulhane Haydarpasa Military Medical School, Uskudar, 34670, Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis / etiology,  physiopathology
Brachial Artery / drug effects,  physiology,  ultrasonography
Echocardiography, Doppler / methods
Endothelium, Vascular / drug effects,  physiopathology*,  ultrasonography
Humans
Male
Nitroglycerin / diagnostic use
Psoriasis / complications,  physiopathology*,  ultrasonography
Vasodilation / drug effects,  physiology
Young Adult
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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