Document Detail

Noninvasive assessment of the digital volume pulse. Comparison with the peripheral pressure pulse.
MedLine Citation:
PMID:  11116106     Owner:  NLM     Status:  MEDLINE    
The digital volume pulse can be recorded simply and noninvasively by photoplethysmography. The objective of the present study was to determine whether a generalized transfer function can be used to relate the digital volume pulse to the peripheral pressure pulse and, hence, to determine whether both volume and pressure pulse waveforms are influenced by the same mechanism. The digital volume pulse was recorded by photoplethysmography in 60 subjects (10 women, aged 24 to 80 years), including 20 subjects with previously diagnosed hypertension. Simultaneous recordings of the peripheral radial pulse and digital artery pulse were obtained by applanation tonometry and a servocontrolled pressure cuff (Finapres), respectively. In 20 normotensive subjects, measurements were obtained after the administration of nitroglycerin (NTG, 500 microgram sublingually). Transfer functions obtained by Fourier analysis of the waveforms were similar in normotensive and hypertensive subjects. In normotensive subjects, transfer functions were similar before and after NTG. By use of a single generalized transfer function for all subjects, the radial and digital artery pressure waveforms could be predicted from the volume pulse with an average root mean square error of 4.4+/-2.0 and 4.3+/-1.9 mm Hg (mean+/-SD) for radial and digital artery waveforms, respectively, similar to the error between the 2 pressure waveforms (4.4+/-1.4 mm Hg). The peripheral pressure pulse is related to the digital volume pulse by a transfer function, which is not influenced by effects of hypertension or NTG. Effects of NTG on the volume pulse and pressure pulse are likely to be determined by a similar mechanism.
S C Millasseau; F G Guigui; R P Kelly; K Prasad; J R Cockcroft; J M Ritter; P J Chowienczyk
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  36     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-26     Completed Date:  2001-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  952-6     Citation Subset:  IM    
Department of Clinical Pharmacology, Centre for Cardiovascular Biology and Medicine, King's College, London, UK.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Blood Pressure Determination / methods*
Hypertension / physiopathology
Nitroglycerin / pharmacology
Tonometry, Ocular
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

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