Document Detail


Noninvasive assessment of acute cardiopulmonary effects of an oral single dose of sildenafil in patients with idiopathic pulmonary hypertension.
MedLine Citation:
PMID:  20676840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We aimed to assess the acute cardiopulmonary effects of a 100-mg oral single dose of sildenafil in patients with idiopathic pulmonary hypertension (IPAH) using a well-validated but less-used noninvasive echocardiographic method for the measurement of both systolic and diastolic pulmonary artery pressure (PAP), by tricuspid regurgitation (TR) velocity curve analysis. We studied 12 consecutive patients with IPAH (10 patients with New York Heart Association functional class III, and 2 patients with functional class II). A 100-mg oral single dose of sildenafil was added to previous medications of all patients and its immediate effects were evaluated 1, 5, and 12 h after treatment. Using paired analysis, administration of a 100-mg oral single dose of sildenafil led to a significant reduction in mean PAP and a remarkable increase in pulmonary acceleration time (PAT) 1 h after treatment (P = 0.000; 95% confidence interval [CI] 18.99-26.00 and P = 0.005; 95% CI -12.89 to -2.95, respectively). In addition, although the right heart dimensions (right atrium and right ventricle) showed a trend toward improvement, the differences were not statistically significant (P = 0.13 and P = 0.08, respectively). Our results demonstrated that Doppler examination of TR alone can be easily used for the estimate of systolic and diastolic PAP in patients with IPAH. This study also shows that sildenafil is the only drug given orally that can evaluate the vasodilatory capacity of the pulmonary vascular bed in patients with IPAH, with promising effects on mPAP and PAT in these patients.
Authors:
Neda Behzadnia; Katayoun Najafizadeh; Babak Sharif-Kashani; Davoud Oulad Dameshghi; Payman Shahabi
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2010-07-31
Journal Detail:
Title:  Heart and vessels     Volume:  25     ISSN:  1615-2573     ISO Abbreviation:  Heart Vessels     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  313-8     Citation Subset:  IM    
Affiliation:
Cardiovascular Department, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shaheed Beheshti University of Medical Sciences and Health Services, Darabad, Shaheed Bahonar Avenue, PO: 19575/154, Tehran 19556, Iran.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Antihypertensive Agents / administration & dosage*,  adverse effects
Blood Flow Velocity / drug effects
Blood Pressure / drug effects*
Echocardiography, Doppler*
Female
Humans
Hypertension, Pulmonary / drug therapy*,  physiopathology,  ultrasonography*
Iran
Male
Middle Aged
Phosphodiesterase Inhibitors / administration & dosage*,  adverse effects
Piperazines / administration & dosage*,  adverse effects
Predictive Value of Tests
Prospective Studies
Pulmonary Artery / drug effects*,  physiopathology
Pulmonary Circulation / drug effects
Purines / administration & dosage,  adverse effects
Sulfones / administration & dosage*,  adverse effects
Time Factors
Treatment Outcome
Tricuspid Valve Insufficiency / physiopathology,  ultrasonography
Vasodilator Agents / administration & dosage*,  adverse effects
Young Adult
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

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