Document Detail


Noninvasive Ventilation and Alveolar Recruitment Maneuver Improve Respiratory Function during and after Intubation of Morbidly Obese Patients: A Randomized Controlled Study.
MedLine Citation:
PMID:  21478734     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND:: Morbid obesity predisposes patients to lung collapse and hypoxemia during induction of anesthesia. The aim of this prospective study was to determine whether noninvasive positive pressure ventilation (NPPV) improves arterial oxygenation and end-expiratory lung volume (EELV) compared with conventional preoxygenation, and whether NPPV followed by early recruitment maneuver (RM) after endotracheal intubation (ETI) further improves oxygenation and respiratory function compared with NPPV alone. METHODS:: Sixty-six consecutive patients (body mass index, 46 ± 6 kg/m) were randomized to receive 5 min of either conventional preoxygenation with spontaneous breathing of 100% O2 (CON), NPPV (pressure support and positive end-expiratory pressure), or NPPV followed by RM (NPPV+RM). Gas exchange was measured in awake patients, at the end of preoxygenation, immediately after ETI, and 5 min after the onset of mechanical ventilation. EELV was measured immediately after ETI and 5 min after mechanical ventilation. The primary endpoint was arterial oxygenation 5 min after the onset of mechanical ventilation. Results are presented as mean ± SD. RESULTS:: At the end of preoxygenation, Pao2 was higher in the NPPV and NPPV+RM groups (382 ± 87 mmHg and 375 ± 82 mmHg, respectively; both P < 0.001) compared with the CON group (306 ± 51 mmHg) and remained higher after ETI (225 ± 104 mmHg and 221 ± 110 mmHg, in the NPPV and NPPV+RM groups, respectively; both P < 0.01 compared with the CON group [150 ± 50 mmHg]). After the onset of mechanical ventilation, Pao2 was 93 ± 25 mmHg in the CON group, 128 ± 54 mmHg in the NPPV group (P = 0.035 vs. CON group), and 234 ± 73 mmHg in the NPPV+RM group (P < 0.0001 vs. NPPV group). After ETI, EELV was higher in the NPPV group compared with the CON group (P < 0.001). Compared with NPPV alone, RM further improved gas exchange and EELV (all P < 0.05). A significant correlation was found between Pao2 obtained 5 min after mechanical ventilation and EELV (R = 0.41, P < 0.001). CONCLUSION:: NPPV improves oxygenation and EELV in morbidly obese patients compared with conventional preoxygenation. NPPV combined with early RM is more effective than NPPV alone at improving respiratory function after ETI.
Authors:
Emmanuel Futier; Jean-Michel Constantin; Paolo Pelosi; Gerald Chanques; Alexandre Massone; Antoine Petit; Fabrice Kwiatkowski; Jean-Etienne Bazin; Samir Jaber
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-8
Journal Detail:
Title:  Anesthesiology     Volume:  -     ISSN:  1528-1175     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
* Assistant Professor of Anesthesiology and Critical Care, ∥ Research Fellow, # Research Fellow, Staff Anesthesiologist, Department of Anesthesiology and Critical Care Medicine, Estaing Hospital, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France. † Professor of Anesthesiology and Critical Care, Director of Surgical Intensive Care Unit, Department of Anesthesiology and Critical Care Medicine, Estaing Hospital, University Hospital of Clermont-Ferrand. ‡ Professor of Anesthesiology and Critical Care, Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate. Universita' degli Studi di Genova, Genova, Italy. § Assistant Professor of Anesthesiology and Critical Care, Head of Intensive Care Unit, ‡‡ Professor of Anesthesiology and Critical Care, Head of Department, Department of Critical Care Medicine and Anesthesiology (SAR B), Saint Eloi Hospital, University Hospital of Montpellier, Montpellier, France. ** Statistician, Department of Statistics, Centre Jean Perrin, University Hospital of Clermont-Ferrand. †† Professor of Anesthesiology and Critical Care, Department of Anesthesiology and Critical Care Medicine, Estaing Hospital, University Hospital of Clermont-Ferrand.
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