| Noninvasive Stratum Corneum Sampling and Electron Microscopical Examination of Skin Barrier Integrity: Pilot Study with a Topical Glycerin Formulation for Atopic Dermatitis. | |
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MedLine Citation:
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PMID: 22399038 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Therapy of atopic dermatitis encloses use of medicated and nonmedicated preparations. Results of clinical and biophysical procedures indirectly describe the condition of the impaired skin barrier (SB). Direct evaluation of SB integrity is only possible by electron microscopical visualization, e.g. intercellular lipid lamellae (ICLL) organization of the stratum corneum. Method: SB integrity was measured by morphometric analysis of ICLL in healthy and atopic skin and after a 15-day treatment (plus 7-day follow-up) of atopic skin with a glycerin preparation. Results: Significant treatment effect was shown by the restoration of the ICLL. Conclusions: The study reveals that morphometric analysis of ICLL organization is suitable to differentiate between healthy and diseased skin and to semiquantitatively determine the effect of a nonmedicated glycerin formulation. Limitation: Small treatment cohort. |
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Authors:
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S Daehnhardt-Pfeiffer; C Surber; K-P Wilhelm; D Daehnhardt; G Springmann; M Boettcher; R Foelster-Holst |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-06 |
Journal Detail:
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Title: Skin pharmacology and physiology Volume: 25 ISSN: 1660-5535 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101188418 Medline TA: Skin Pharmacol Physiol Country: - |
Other Details:
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Languages: ENG Pagination: 155-161 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Spirig Pharma AG, Egerkingen, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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