Document Detail

Noninvasive reconstruction of the three-dimensional ventricular activation sequence during pacing and ventricular tachycardia in the canine heart.
MedLine Citation:
PMID:  21984548     Owner:  NLM     Status:  MEDLINE    
Single-beat imaging of myocardial activation promises to aid in both cardiovascular research and clinical medicine. In the present study we validate a three-dimensional (3D) cardiac electrical imaging (3DCEI) technique with the aid of simultaneous 3D intracardiac mapping to assess its capability to localize endocardial and epicardial initiation sites and image global activation sequences during pacing and ventricular tachycardia (VT) in the canine heart. Body surface potentials were measured simultaneously with bipolar electrical recordings in a closed-chest condition in healthy canines. Computed tomography images were obtained after the mapping study to construct realistic geometry models. Data analysis was performed on paced rhythms and VTs induced by norepinephrine (NE). The noninvasively reconstructed activation sequence was in good agreement with the simultaneous measurements from 3D cardiac mapping with a correlation coefficient of 0.74 ± 0.06, a relative error of 0.29 ± 0.05, and a root mean square error of 9 ± 3 ms averaged over 460 paced beats and 96 ectopic beats including premature ventricular complexes, couplets, and nonsustained monomorphic VTs and polymorphic VTs. Endocardial and epicardial origins of paced beats were successfully predicted in 72% and 86% of cases, respectively, during left ventricular pacing. The NE-induced ectopic beats initiated in the subendocardium by a focal mechanism. Sites of initial activation were estimated to be ∼7 mm from the measured initiation sites for both the paced beats and ectopic beats. For the polymorphic VTs, beat-to-beat dynamic shifts of initiation site and activation pattern were characterized by the reconstruction. The present results suggest that 3DCEI can noninvasively image the 3D activation sequence and localize the origin of activation of paced beats and NE-induced VTs in the canine heart with good accuracy. This 3DCEI technique offers the potential to aid interventional therapeutic procedures for treating ventricular arrhythmias arising from epicardial or endocardial sites and to noninvasively assess the mechanisms of these arrhythmias.
Chengzong Han; Steven M Pogwizd; Cheryl R Killingsworth; Bin He
Related Documents :
22660318 - Heart repair by reprogramming non-myocytes with cardiac transcription factors.
20859528 - The violin heart.
8879948 - Quantitative echocardiography in left ventricular remodeling after myocardial infarction.
21716908 - Kappa-opioid receptor activation during reperfusion limits myocardial infarction via er...
24445228 - Sudden cardiac death risk stratification in patients with nonischemic dilated cardiomyo...
24174858 - Potential pro-arrhythmic effect of cardiac resynchronization therapy.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2011-10-07
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  302     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-27     Completed Date:  2012-02-14     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H244-52     Citation Subset:  IM    
Department of Biomedical Engineering, University of Minnesota, Minneapolis, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Action Potentials
Cardiac Pacing, Artificial*
Disease Models, Animal
Heart Conduction System / physiopathology*,  radiography
Heart Ventricles / physiopathology*,  radiography
Imaging, Three-Dimensional*
Models, Cardiovascular
Predictive Value of Tests
Reproducibility of Results
Tachycardia, Ventricular / chemically induced,  diagnosis*,  physiopathology
Time Factors
Tomography, X-Ray Computed
Ventricular Function, Left*
Ventricular Premature Complexes / chemically induced,  diagnosis*,  physiopathology
Voltage-Sensitive Dye Imaging*
Grant Support
HL-073966/HL/NHLBI NIH HHS; HL-080093/HL/NHLBI NIH HHS; R01 HL073966-04/HL/NHLBI NIH HHS; R01 HL080093-03/HL/NHLBI NIH HHS; R01 HL080093-04/HL/NHLBI NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the h...
Next Document:  Mechanism of Prolonged Electro-Mechanical Delay in Late Activated Myocardium during Left Bundle Bran...