| Noninvasive prenatal diagnosis: 2010. | |
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MedLine Citation:
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PMID: 20638579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Looking for fetal cells and now nucleic acids has been the holy grail of prenatal diagnosis for more than a century. The use of noninvasive diagnostics has potential far beyond aneuploidy; in fact, its use for Rhesus disease is already commonplace in Europe. Accurate segregation of fetal cells from maternal cells or identification of cell-free fetal (cff) DNA or RNA is critical to the development of fetal cells as a screening or diagnostic prenatal technique. The large number of approaches that have been used is testimony to the fact that none of them have been particularly successful. This article discusses the current status and challenges of noninvasive prenatal diagnosis. |
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Authors:
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Mark I Evans; Michael Kilpatrick |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinics in laboratory medicine Volume: 30 ISSN: 1557-9832 ISO Abbreviation: Clin. Lab. Med. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100174 Medline TA: Clin Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 655-65 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Fetal Medicine Foundation of America, New York, NY, USA. evans@compregen.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cervix Uteri
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cytology DNA / analysis Female Fetus / cytology Humans Mass Screening / adverse effects, methods Maternal-Fetal Exchange Pregnancy Prenatal Diagnosis / adverse effects, methods* RNA / analysis Risk Assessment Trophoblasts / chemistry |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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