Document Detail


Noninvasive prenatal diagnosis: 2010.
MedLine Citation:
PMID:  20638579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Looking for fetal cells and now nucleic acids has been the holy grail of prenatal diagnosis for more than a century. The use of noninvasive diagnostics has potential far beyond aneuploidy; in fact, its use for Rhesus disease is already commonplace in Europe. Accurate segregation of fetal cells from maternal cells or identification of cell-free fetal (cff) DNA or RNA is critical to the development of fetal cells as a screening or diagnostic prenatal technique. The large number of approaches that have been used is testimony to the fact that none of them have been particularly successful. This article discusses the current status and challenges of noninvasive prenatal diagnosis.
Authors:
Mark I Evans; Michael Kilpatrick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in laboratory medicine     Volume:  30     ISSN:  1557-9832     ISO Abbreviation:  Clin. Lab. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100174     Medline TA:  Clin Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  655-65     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Fetal Medicine Foundation of America, New York, NY, USA. evans@compregen.com
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MeSH Terms
Descriptor/Qualifier:
Cervix Uteri / cytology
DNA / analysis
Female
Fetus / cytology
Humans
Mass Screening / adverse effects,  methods
Maternal-Fetal Exchange
Pregnancy
Prenatal Diagnosis / adverse effects,  methods*
RNA / analysis
Risk Assessment
Trophoblasts / chemistry
Chemical
Reg. No./Substance:
63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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