Document Detail

Noninvasive prediction of left ventricular end-diastolic pressure in patients with coronary artery disease and preserved ejection fraction.
MedLine Citation:
PMID:  21723693     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to compare 3 different available methods for estimating left ventricular end-diastolic pressure (LVEDP) noninvasively in patients with coronary artery disease and preserved left ventricular ejection fraction (EF).
METHODS: We used 3 equations for noninvasive estimation of LVEDP: The equation of Mulvagh et al., LVEDP(1) = 46 - 0.22 (IVRT) - 0.10 (AFF) - 0.03 (DT) - (2 ÷ E/A) + 0.05 MAR; the equation of Stork et al., LVEDP(2) = 1.06 + 15.15 × Ai/Ei; and the equation of Abd-El-Aziz, LVEDP(3) = [0.54 (MABP) × (1 - EF)] - 2.23. (
ABBREVIATIONS: A, A-wave velocity; AFF, atrial filling fraction; Ai, time velocity integral of A wave; DT, deceleration time; E, E-wave velocity; Ei, time velocity integral of E wave; IVRT, isovolumic relaxation time; MABP, mean arterial blood pressure; MAR, time from termination of mitral flow to the electrocardiographic R wave; Ti, time velocity integral of total wave.)
RESULTS: LVEDP measured by catheterization was correlated with LVEDP(1) (r = 0.52, P < 0.001), LVEDP(2) (r = 0.31, P < 0.05), and LVEDP(3) (r = 0.81, P < 0.001).
CONCLUSIONS: The equation described by Abd-El-Aziz, LVEDP = [0.54 MABP × (1 - EF)] - 2.23, appears to be the most accurate, reliable, and easily applied method for estimating LVEDP noninvasively in patients with preserved left ventricular ejection fraction and an LVEDP < 20 mm Hg.
Tarek A Abd-El-Aziz
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-07-02
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  28     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-03-20     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  80-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Cardiac Catheterization / methods*
Coronary Angiography
Coronary Artery Disease / diagnosis,  physiopathology*
Echocardiography, Doppler / methods*
Follow-Up Studies
Middle Aged
Predictive Value of Tests
ROC Curve
Severity of Illness Index
Stroke Volume / physiology*
Ventricular Function, Left / physiology*
Ventricular Pressure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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