Document Detail


A Noninvasive Metabolic Syndrome Model Using an Extremely Small Minipig, the Microminipig.
MedLine Citation:
PMID:  25242170     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for inhibiting nitric oxide synthase. HFCD significantly increased serum low-density lipoprotein levels, l-NAME increased blood pressure and cardiac hypertrophy, and HFCD-induced aortal arteriosclerosis was accelerated by l-NAME administration. Endothelium-dependent relaxation of the coronary artery was remarkably decreased by l-NAME administration. This model may be useful for elucidating the mechanisms of MetS and developing new therapeutic medicines for its treatment.
Authors:
Takehiro Yamaguchi; Takanori Yamazaki; Hiroaki Kawaguchi; Masashi Tawa; Yasuhiro Nakamura; Masayuki Shiota; Mayuko Osada-Oka; Akihide Tanimoto; Tomio Okamura; Katsuyuki Miura; Hiroshi Iwao; Minoru Yoshiyama; Yasukatsu Izumi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-19
Journal Detail:
Title:  Journal of pharmacological sciences     Volume:  -     ISSN:  1347-8648     ISO Abbreviation:  J. Pharmacol. Sci.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167001     Medline TA:  J Pharmacol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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