Document Detail


Noninvasive measurement of skin autofluorescence is increased in patients with systemic sclerosis: an indicator of increased advanced glycation endproducts?
MedLine Citation:
PMID:  22753661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Skin autofluorescence noninvasively assesses expression of advanced glycation endproducts and therefore potentially the presence of oxidative stress that is implicated in the pathogenesis of systemic sclerosis (SSc). We investigated whether autofluorescence was increased in patients with SSc, primary Raynaud's phenomenon (RP), and morphea as compared to healthy controls.
METHODS: Measurements of autofluorescence were made at 5 upper limb sites in 16 healthy controls, 16 patients with diffuse cutaneous SSc (dcSSc), 15 with limited cutaneous SSc (lcSSc), 15 with primary RP, and 13 with morphea. For patients with morphea, additional measurements were made at the affected and an adjacent unaffected site.
RESULTS: Autofluorescence was significantly increased in patients with dcSSc but not lcSSc as compared to controls at the proximal phalanx [dcSSc median 0.15, interquartile range (IQR) 0.10-0.24, vs control 0.10, IQR 0.07-0.13; p = 0.014], dorsum of the hand (dcSSc 0.17, IQR 0.11-0.36, vs control 0.12, IQR 0.09-0.17; p = 0.031), the wrist (dcSSc 0.22, IQR 0.13-0.33, vs control 0.13, IQR 0.09-0.18; p = 0.005), and forearm (dcSSc 0.19, IQR 0.12-0.47, vs control 0.14, IQR 0.10-0.16; p = 0.022). There was a trend for autofluorescence to be increased in patients with lcSSc and at morphea sites, compared to noninvolved skin.
CONCLUSION: Autofluorescence is increased in patients with dcSSc compared to primary RP and to healthy controls. This suggests increased oxidative stress and the potential for autofluorescence as a biomarker.
Authors:
Andrea K Murray; Tonia L Moore; Joanne B Manning; Christopher E M Griffiths; Ariane L Herrick
Publication Detail:
Type:  Journal Article     Date:  2012-07-01
Journal Detail:
Title:  The Journal of rheumatology     Volume:  39     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-03     Completed Date:  2013-01-16     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1654-8     Citation Subset:  IM    
Affiliation:
Musculoskeletal Research Group, School of Translational Medicine, Salford Royal NHS Foundation, Manchester M6 8HD, UK. Andrea.murray@manchester.ac.uk.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Glycosylation End Products, Advanced / metabolism*
Humans
Male
Middle Aged
Optical Imaging
Oxidative Stress
Raynaud Disease / metabolism,  pathology
Scleroderma, Localized / metabolism,  pathology
Scleroderma, Systemic / metabolism*,  pathology
Skin / metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Glycosylation End Products, Advanced
Comments/Corrections
Comment In:
J Rheumatol. 2013 Feb;40(2):206   [PMID:  23487862 ]
J Rheumatol. 2013 Feb;40(2):206   [PMID:  23378499 ]

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