| Noninvasive imaging surrogate of angiogenesis in osteosarcoma. | |
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MedLine Citation:
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PMID: 19890899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Measurement of tumor angiogenesis by qualitative analysis of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI), and its association with diffusion-weighted (DW)-MRI and glucose metabolism using positron emission tomography-computerized tomography (PET-CT) scan has not been explored in osteosarcoma. Present study was aimed to evaluate the potential of these surrogates. PATIENTS AND METHODS: Thirty-one treatment naive patients with osteosarcoma underwent MRI and PET-CT preceding and following three cycles of neoadjuvant chemotherapy (NACT) and surgery. Time intensity curves (TICs) representing low microvascular permeability is persistent type while that of high permeability are plateau and washout types. Vascular endothelial growth factor (VEGF) expression was assessed in biopsy and resected specimens by immunohistochemistry. The sample was considered VEGF positive when intensive positive staining of VEGF was observed in >10% of the tumor cells in biopsy or resection specimens. RESULTS: TIC could correctly identify all 28 VEGF positive samples at baseline and 24/25 (96%) of VEGF positive samples and 5/6 (83%) of VEGF negative samples after NACT. The change in curve pattern from washout/plateau to persistent type was in agreement with corresponding decrease in microvascular permeability, that is, VEGF expression. For persistent type of TIC, mean change in VEGF was 73.3 +/- 43.2% and for plateau and washout type of TIC it was 19.54 +/- 45% and 16.66 +/- 28.86%, respectively (P <or= 0.04). VEGF expression did not correlate with DW-MRI and PET-CT parameters. CONCLUSION: This study suggests an important role of DCE-MRI as a noninvasive imaging surrogate of tumor angiogenesis in osteosarcoma based on visual inspection of TIC. |
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Authors:
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Jyoti Bajpai; Shivanand Gamanagatti; Mehar C Sharma; Rakesh Kumar; Sreenivas Vishnubhatla; Shah Alam Khan; Shishir Rastogi; Arun Malhotra; Sameer Bakhshi |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 54 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-04-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 526-31 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Bone Neoplasms / blood supply, metabolism, pathology* Child Child, Preschool Female Humans Image Enhancement Immunohistochemistry Magnetic Resonance Imaging / methods* Male Middle Aged Neovascularization, Pathologic / pathology* Osteosarcoma / blood supply, metabolism, pathology* Positron-Emission Tomography Tumor Markers, Biological / analysis Vascular Endothelial Growth Factor A / biosynthesis* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; 0/Vascular Endothelial Growth Factor A |
| Comments/Corrections | |
Comment In:
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Pediatr Blood Cancer. 2010 Apr;54(4):497-8
[PMID:
20091706
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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