Document Detail


Noninvasive fetal lung maturity prediction based on ultrasonic gray level histogram width.
MedLine Citation:
PMID:  20950934     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The aim of this work was to noninvasively predict fetal lung immaturity with the ultrasonic gray level histogram width (GLHW), a form of clinical tissue characterization. The study included 22 fetuses in which infant respiratory distress syndrome (IRDS) developed post-delivery, and 25 fetuses without IRDS development. Independent receiver operating characteristic (ROC) analysis of fetal lung-to-liver GLHW ratios, fetal weights, gestational ages and the product of GLHW ratios by gestational ages for this cohort indicated that optimal thresholds for these parameters to differentiate immature from mature were 0.94, 1.750 g, 31 weeks and 29, respectively. With the optimal decision threshold of 0.94, the GLHW ratio provided sensitivity and specificity of 0.86 and 0.72, respectively. The corresponding values for gestational age were 0.77 and 0.68, 0.77 and 0.60 for fetal weight versus 0.96 and 0.72 for the product of GLHW ratio by fetal age, which was comparable with invasive amniotic fluid tests. The areas under the ROC curve for these parameters were 0.82, 0.82, 0.70 and 0.91. We found that GLHW is a noninvasive, stable and reliable measure of fetal lung maturity using commercial scanners.
Authors:
Mariko Serizawa; Kazuo Maeda
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Publication Detail:
Type:  Journal Article     Date:  2010-10-15
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  36     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1998-2003     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Hamamatsu Medical Center, Hamamatsu, Japan. serizawa@hmedc.or.jp
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