Document Detail


Noninvasive creation of an atrial septal defect by histotripsy in a canine model.
MedLine Citation:
PMID:  20124126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The primary objective of this study was to develop an image-guided, noninvasive procedure to create or enlarge an atrial septal defect for the treatment of neonates with hypoplastic left heart syndrome and an intact or restrictive atrial septum. Histotripsy is an innovative ultrasonic technique that produces nonthermal, mechanical tissue fractionation through the use of high-intensity ultrasound pulses. This article reports the pilot in vivo study to create an atrial septal defect through the use of extracardiac application of histotripsy in an open-chest canine model.
METHODS AND RESULTS: In 10 canines, the atrial septum was exposed to histotripsy by an ultrasound transducer positioned outside the heart. Ultrasound pulses of 6-microsecond duration at a peak negative pressure of 15 MPa and a pulse repetition frequency of 3.3 kHz were generated by a 1-MHz focused transducer. The procedure was guided and monitored by real-time ultrasound imaging. In 9 of 10 canines, an atrial septal defect was produced, and shunting across the atrial septum was visualized. Pathology of the hearts showed atrial septal defects with minimal damage to surrounding tissue. No damage was found on the epicardial surface of the heart or other structures.
CONCLUSIONS: Under real-time ultrasound guidance, atrial septal defects were successfully created with extracardiac histotripsy in a live canine model. Although further studies in an intact animal model are needed, these results provide promise of histotripsy becoming a valuable clinical tool.
Authors:
Zhen Xu; Gabe Owens; David Gordon; Charles Cain; Achi Ludomirsky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-02-01
Journal Detail:
Title:  Circulation     Volume:  121     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-03-31     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  742-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Septum / pathology,  ultrasonography
Disease Models, Animal*
Dogs
Embolism / epidemiology
Heart Septal Defects, Atrial / etiology*,  pathology,  ultrasonography
Humans
Hypoplastic Left Heart Syndrome / ultrasonography
Infant, Newborn
Pilot Projects
Risk Factors
Ultrasonics / adverse effects*
Ultrasonography, Doppler, Color
Grant Support
ID/Acronym/Agency:
R01 HL077629/HL/NHLBI NIH HHS; R01 HL077629-04/HL/NHLBI NIH HHS; R01-HL077629/HL/NHLBI NIH HHS
Comments/Corrections

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