| Noninvasive brachial-ankle pulse wave velocity in hypertensive patients with left ventricular hypertrophy. | |
| | |
MedLine Citation:
|
PMID: 20010700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The elevation of left ventricular filling pressure (LVFP) could be an important prognostic factor in patients with hypertension. We hypothesized that noninvasive brachial-ankle pulse wave velocity (baPWV) is associated with increased LVFP in hypertensive patients with LV hypertrophy (LVH). METHODS: We enrolled patients with well-controlled hypertension for more than 1 year with LV ejection fraction (LVEF) > or = 55%, and LVH. The relationship between Doppler echocardiographic parameters of LVFP and baPWV with B-type natriuretic peptide (BNP) was also evaluated. RESULTS: A total of 62 patients were enrolled (31 patients with E/E(a) >15 and 31 patients with E/Ea < or = 15) and the baPWV of the E/Ea >15 group was significantly increased compared to the E/Ea < or = 15 group (1,664.3 +/- 270.5 vs. 1,381.9 +/- 159.1 cm/s, P < 0.01). The baPWV showed better correlation with E/Ea (r = 0.69, P < 0.01) than the BNP (r = 0.47, P < 0.01). A multivariate linear regression model showed that only baPWV was significantly correlated with E/E(a), and that the association was independent of other factors. The area under the receiver-operating characteristic (ROC) curve of baPWV for the detection of elevated LVFP (E/Ea >15) was 0.79 (P < 0.01) and the optimal cutoff point of 1,440 cm/s produced 75% sensitivity and 62% specificity (the positive and negative predictive values were 68 and 71%, respectively). CONCLUSIONS: In this study, we have demonstrated that elevated baPWV is associated with noninvasive markers of increased LVFP in hypertensive LVH patients with preserved LV systolic function. |
| | |
Authors:
|
Kyoung-Ha Park; Woo Jung Park; Min-Kyu Kim; Jae-Hun Jung; Seonghoon Choi; Jung Rae Cho; Hyun-Sook Kim; Namho Lee; Goo-Yeong Cho |
Publication Detail:
|
Type: Journal Article Date: 2009-12-10 |
Journal Detail:
|
Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-15 Completed Date: 2010-04-29 Revised Date: 2011-06-30 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 269-74 Citation Subset: IM |
Affiliation:
|
Cardiovascular Division, Department of Internal Medicine, Hallym University Medical Center, Seoul, Korea. pkhmd@naver.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Ankle Ankle Brachial Index / methods* Brachial Artery / physiopathology* Echocardiography, Doppler Female Humans Hypertension / complications, physiopathology* Hypertrophy, Left Ventricular / etiology, physiopathology* Male Middle Aged Pulsatile Flow Stroke Volume Systole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Haplotype-based case-control study on human apurinic/apyrimidinic endonuclease 1/redox effector fact...
Next Document: Hospitalization costs associated with hypertension as a secondary diagnosis among insured patients a...