Document Detail

Noninvasive brachial-ankle pulse wave velocity in hypertensive patients with left ventricular hypertrophy.
MedLine Citation:
PMID:  20010700     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The elevation of left ventricular filling pressure (LVFP) could be an important prognostic factor in patients with hypertension. We hypothesized that noninvasive brachial-ankle pulse wave velocity (baPWV) is associated with increased LVFP in hypertensive patients with LV hypertrophy (LVH).
METHODS: We enrolled patients with well-controlled hypertension for more than 1 year with LV ejection fraction (LVEF) > or = 55%, and LVH. The relationship between Doppler echocardiographic parameters of LVFP and baPWV with B-type natriuretic peptide (BNP) was also evaluated.
RESULTS: A total of 62 patients were enrolled (31 patients with E/E(a) >15 and 31 patients with E/Ea < or = 15) and the baPWV of the E/Ea >15 group was significantly increased compared to the E/Ea < or = 15 group (1,664.3 +/- 270.5 vs. 1,381.9 +/- 159.1 cm/s, P < 0.01). The baPWV showed better correlation with E/Ea (r = 0.69, P < 0.01) than the BNP (r = 0.47, P < 0.01). A multivariate linear regression model showed that only baPWV was significantly correlated with E/E(a), and that the association was independent of other factors. The area under the receiver-operating characteristic (ROC) curve of baPWV for the detection of elevated LVFP (E/Ea >15) was 0.79 (P < 0.01) and the optimal cutoff point of 1,440 cm/s produced 75% sensitivity and 62% specificity (the positive and negative predictive values were 68 and 71%, respectively).
CONCLUSIONS: In this study, we have demonstrated that elevated baPWV is associated with noninvasive markers of increased LVFP in hypertensive LVH patients with preserved LV systolic function.
Kyoung-Ha Park; Woo Jung Park; Min-Kyu Kim; Jae-Hun Jung; Seonghoon Choi; Jung Rae Cho; Hyun-Sook Kim; Namho Lee; Goo-Yeong Cho
Publication Detail:
Type:  Journal Article     Date:  2009-12-10
Journal Detail:
Title:  American journal of hypertension     Volume:  23     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-04-29     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  IM    
Cardiovascular Division, Department of Internal Medicine, Hallym University Medical Center, Seoul, Korea.
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MeSH Terms
Ankle Brachial Index / methods*
Brachial Artery / physiopathology*
Echocardiography, Doppler
Hypertension / complications,  physiopathology*
Hypertrophy, Left Ventricular / etiology,  physiopathology*
Middle Aged
Pulsatile Flow
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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