| Noninvasive Assessment of Liver Fibrosis in Patients after the Fontan Operation. | |
| | |
MedLine Citation:
|
PMID: 22044772 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background This study analyzed the change in liver fibrosis markers after the Fontan operation and investigated their clinical usefulness as an index of congestive liver fibrosis. Methods The study enrolled 24 patients who underwent the Fontan operation between January 1994 and December 2008. We subdivided the postoperative period into four intervals and then compared the hepatological markers during each. Eighteen patients underwent postoperative cardiac catheterization and the relationship between hepatological markers and the inferior vena cava (IVC) pressure was analyzed. Results The mean age of the patients was 138.6 months and the mean interval between the Fontan operation and the examination was 97.8 months. Type IV collagen was extremely high in every interval (I, 286 ± 93; II, 265 ± 93; III, 305 ± 143; IV, 206 ± 70), while none of the laboratory variables changed significantly in each interval. A significant positive correlation was observed between type IV collagen and the IVC pressure, but no significant correlation with any other hepatological marker was detected. Conclusions No specific parameter that reflects the progress in liver fibrosis was identified in this study. The possibility exists that type IV collagen reflects the degree of hepatic congestion. |
| | |
Authors:
|
Takeshi Furukawa; Katsumi Akimoto; Masahiro Ohtsuki; Keiko Sato; Mitsuyoshi Suzuki; Ken Takahashi; Masahiko Kishiro; Toshiaki Shimizu; Shiori Kawasaki |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-1 |
Journal Detail:
|
Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: - ISSN: 1442-200X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society. |
Affiliation:
|
Department of Pediatrics, Juntendo University School of Medicine Department of Cardiovascular Surgery, Juntendo University School of Medicine. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Simultaneous cell growth and ethanol production from cellulose by an engineered yeast consortium dis...
Next Document: Polymerization profile analysis of resin composite dental restorative materials in real time.