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Noninvasive Assessment of Liver Fibrosis in Patients after the Fontan Operation.
MedLine Citation:
PMID:  22044772     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background  This study analyzed the change in liver fibrosis markers after the Fontan operation and investigated their clinical usefulness as an index of congestive liver fibrosis. Methods The study enrolled 24 patients who underwent the Fontan operation between January 1994 and December 2008. We subdivided the postoperative period into four intervals and then compared the hepatological markers during each. Eighteen patients underwent postoperative cardiac catheterization and the relationship between hepatological markers and the inferior vena cava (IVC) pressure was analyzed. Results  The mean age of the patients was 138.6 months and the mean interval between the Fontan operation and the examination was 97.8 months. Type IV collagen was extremely high in every interval (I, 286 ± 93; II, 265 ± 93; III, 305 ± 143; IV, 206 ± 70), while none of the laboratory variables changed significantly in each interval. A significant positive correlation was observed between type IV collagen and the IVC pressure, but no significant correlation with any other hepatological marker was detected. Conclusions  No specific parameter that reflects the progress in liver fibrosis was identified in this study. The possibility exists that type IV collagen reflects the degree of hepatic congestion.
Authors:
Takeshi Furukawa; Katsumi Akimoto; Masahiro Ohtsuki; Keiko Sato; Mitsuyoshi Suzuki; Ken Takahashi; Masahiko Kishiro; Toshiaki Shimizu; Shiori Kawasaki
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-1
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.
Affiliation:
Department of Pediatrics, Juntendo University School of Medicine Department of Cardiovascular Surgery, Juntendo University School of Medicine.
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