Document Detail


Noninfectious uveitis and pregnancy.
MedLine Citation:
PMID:  12834675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To report the course of uveitis disease activity during pregnancy and the postpartum period in women with noninfectious uveitis. DESIGN: Observational case series. METHODS: The medical records of women with noninfectious uveitis and pregnancy during follow-up at a large eye hospital were retrospectively reviewed. Patients with pregnancy were included in the study if follow-up was adequate to document the presence or absence of flare-ups in uveitis activity during the pregnancy and/or postpartum period. RESULTS: Seventy-six pregnancies among 50 women were included in the study. Thirty-three pregnancies were in women with Vogt-Koyanagi-Harada disease, 19 were in women with Behcet disease, and 24 were in women with idiopathic uveitis. A flare-up in uveitis activity occurred within the first 4 months of pregnancy in 49 of 76 cases (64%) and later in pregnancy in 17 cases (22%); no flare-up occurred during pregnancy in 21 cases (28%). An early pregnancy flare-up was typical of Vogt-Koyanagi-Harada disease and idiopathic uveitis. A flare-up within 6 months of delivery occurred in 38 of 59 cases (64%) that had adequate examination data available from the postpartum period. The postpartum flare-up was especially typical of Behcet disease. CONCLUSIONS: Many women with noninfectious uveitis will experience a flare-up in disease activity within the first 4 months of pregnancy. Later pregnancy appears to be a time of relative disease inactivity. Many will experience a rebound in activity within 6 months of delivery.
Authors:
Peter K Rabiah; Albert T Vitale
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  136     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-01     Completed Date:  2003-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. prabiah@enh.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Middle Aged
Postpartum Period
Pregnancy
Pregnancy Complications / physiopathology*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Recurrence
Retrospective Studies
Uveitis / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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