| Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes. | |
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MedLine Citation:
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PMID: 22308462 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations, eventually causing tumors. To identify as-yet-unknown AID targets, we screened early AID-induced DNA breaks by using two independent genome-wide approaches. Along with known AID targets, this screen identified a set of unique genes (SNHG3, MALAT1, BCL7A, and CUX1) and confirmed that these loci accumulated mutations as frequently as Ig locus after AID activation. Moreover, these genes share three important characteristics with the Ig gene: translocations in tumors, repetitive sequences, and the epigenetic modification of chromatin by H3K4 trimethylation in the vicinity of cleavage sites. |
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Authors:
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Lucia Kato; Nasim A Begum; A Maxwell Burroughs; Tomomitsu Doi; Jun Kawai; Carsten O Daub; Takahisa Kawaguchi; Fumihiko Matsuda; Yoshihide Hayashizaki; Tasuku Honjo |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-30 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: - ISSN: 1091-6490 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Immunology and Genomic Medicine and The Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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