Document Detail


Acquired amegakaryocytic thrombocytopenia purpura in a Rhesus macaque (Macaca mulatta).
MedLine Citation:
PMID:  22776057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 10-y-old multiparous rhesus macaque presented for an annual routine physical examination. Clinically, the animal had pale mucous membranes, petechial and ecchymotic hemorrhages in multiple sites, and a laceration at the tail base. Severe pancytopenia was noted on hematologic evaluation. The monkey was seronegative for SIV, simian T-lymphotropic virus, simian retrovirus type D, and Macacine herpesvirus 1. Bone marrow evaluation revealed a paucity of megakaryocytic precursors in a hypercellular marrow with marked erythroid hyperplasia. In light of these findings, the diagnosis was acquired amegakaryocytic thrombocytopenia purpura. Due to the poor prognosis of the syndrome and clinical deterioration of the monkey, euthanasia was elected. A definitive cause of the thrombocytopenia was not identified; however, the syndrome may have developed secondary to a recent spontaneous abortion. To our knowledge, this case represents the first reported observation of acquired amegakaryocytic thrombocytopenia purpura in a rhesus monkey.
Authors:
Patrick W Hanley; Wallace B Baze; Mark J McArthur; Bruce J Bernacky; Greg K Wilkerson; Kirstin F Barnhart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative medicine     Volume:  62     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-10     Completed Date:  2012-11-05     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
Affiliation:
Department of Veterinary Sciences, Michale E Keeling Center for Comparative Medicine and Research, MD Anderson Cancer Center, Bastrop, Texas, USA. phanley@mdanderson.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow Diseases / diagnosis*
Macaca mulatta
Purpura, Thrombocytopenic / diagnosis*
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