| Nonhuman primate models for translational research in endometriosis. | |
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MedLine Citation:
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PMID: 19208783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endometriosis, defined as the ectopic presence of endometrial-like cells, is associated with infertility and pelvic pain in women. Whereas pathogenesis and spontaneous evolution of endometriosis are still poorly understood, recurrences after surgical therapy or after medical treatment are common. Spontaneous endometriosis occurs only in women and in nonhuman primates (NHPs). Inbred rhesus monkeys kept in colonies offer an attractive preclinical model to study the inheritance of spontaneous endometriosis. Baboons with spontaneous or induced endometriosis appear to be the best NHP model to study pathogenesis, pathophysiology, spontaneous evolution and new medical treatment options. In baboons, induction of endometriosis after intrapelvic injection of menstrual endometrium leads to biological changes in peritoneal cavity and in endometrium. This induction process may allows the study of cause-effect relationships which may lead to the discovery of new biomarkers for the development of new non-invasive diagnostic tests and drugs that may prevent or treat endometriosis. |
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Authors:
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T M D'Hooghe; C M Kyama; D Chai; A Fassbender; A Vodolazkaia; A Bokor; J M Mwenda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 16 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-11 Completed Date: 2009-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 152-61 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Leuven, University Fertility Center, University Hospital Gasthuisberg, Leuven, Belgium. thomas.dhooghe@uz.kuleuven.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomedical Research* / economics, ethics Disease Models, Animal* Endometriosis* / diagnosis, etiology, physiopathology, therapy Female Fertility Agents, Female / pharmacology Humans Immunologic Factors / pharmacology Immunosuppressive Agents / pharmacology Infertility, Female / etiology, physiopathology Inflammation / etiology, physiopathology Macaca mulatta* Menstruation Papio* Pelvic Pain / etiology, physiopathology Reproducibility of Results Reproduction Risk Factors Severity of Illness Index Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 0/Immunologic Factors; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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