Document Detail


Nonhuman primate models in AIDS research.
MedLine Citation:
PMID:  23615116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Over the past decades, AIDS research has made tremendous progress in all key areas, including pathogenesis, prevention, and treatment. In particular, the introduction of potent antiretroviral therapy (ART) has dramatically reduced the morbidity and mortality of HIV-infected individuals. However, several challenges remain, including the absence of a vaccine that can reliably prevent virus acquisition, and the inability of current ART regimens to eradicate the infection.
RECENT FINDINGS: Several key advances in HIV/AIDS research have been made possible by the extensive use of animal models and, in particular, the nonhuman primate models of SIV and SHIV infection of various monkey species including macaques, sooty mangabeys, vervets, and others. Key advantages of these models include the ability to control for parameters that are virtually impossible to assess in humans, to extensively study cells and tissues (including elective necropsy), and to perform proof-of-concept studies that would pose unacceptable safety risks in humans.
SUMMARY: In this review, we describe the most recent advances in the use of animal models for HIV/AIDS research, and will break down these advances in three areas: models for virus transmission, dissemination, and pathogenesis; models for virus prevention and vaccines; and models for virus eradication and indefinite virus containment (functional cure) under ART.
Authors:
David T Evans; Guido Silvestri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in HIV and AIDS     Volume:  8     ISSN:  1746-6318     ISO Abbreviation:  Curr Opin HIV AIDS     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-07     Completed Date:  2013-12-18     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  101264945     Medline TA:  Curr Opin HIV AIDS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomedical Research
Disease Models, Animal*
HIV Infections*
Humans
Macaca
Simian Acquired Immunodeficiency Syndrome*
Simian immunodeficiency virus
Grant Support
ID/Acronym/Agency:
AI066998/AI/NIAID NIH HHS; AI087498/AI/NIAID NIH HHS; AI090797/AI/NIAID NIH HHS; AI095098/AI/NIAID NIH HHS; AI098485/AI/NIAID NIH HHS; R01 AI066998/AI/NIAID NIH HHS; R01 AI090797/AI/NIAID NIH HHS; R01 AI095098/AI/NIAID NIH HHS; R01 AI098485/AI/NIAID NIH HHS; R21 AI087498/AI/NIAID NIH HHS; R37 AI066998/AI/NIAID NIH HHS; RR000165/OD011132/OD/NIH HHS; RR000168/OD011103/OD/NIH HHS
Comments/Corrections

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