| Nonhuman primate models of human immunology. | |
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MedLine Citation:
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PMID: 20524846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman primate immune system, with special emphasis on studies carried out in rhesus macaque (Macaca mulatta). We highlight the utility of nonhuman primates in the characterization of immune senescence and the evaluation of new interventions to slow down the aging of the immune system. |
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Authors:
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Ilhem Messaoudi; Ryan Estep; Bridget Robinson; Scott W Wong |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-08-30 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 14 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-16 Completed Date: 2011-07-18 Revised Date: 2012-01-16 |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 261-73 Citation Subset: IM |
Affiliation:
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Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA. messaoud@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dendritic Cells / immunology Humans Immune System / immunology Killer Cells, Natural / immunology Macaca mulatta / immunology* Models, Animal* Models, Immunological* |
| Grant Support | |
ID/Acronym/Agency:
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5P51 RR00163-47/RR/NCRR NIH HHS; 5P51 RR00163-48/RR/NCRR NIH HHS; CA132638-01/CA/NCI NIH HHS; R01 CA075922-14/CA/NCI NIH HHS; R01 CA075922-15/CA/NCI NIH HHS; R01 CA132638-03/CA/NCI NIH HHS; R01 CA132638-04/CA/NCI NIH HHS; T32 AI007472-12/AI/NIAID NIH HHS |
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