Document Detail

Osteochondromatosis in a Rhesus macaque (Macaca mulatta).
MedLine Citation:
PMID:  22546923     Owner:  NLM     Status:  MEDLINE    
A 5-y-old, male, rhesus macaque (Macaca mulatta) presented with a prominent mass slightly anteriomedial to the right stifle. On exam, multiple radiopaque masses were identified protruding from the mid- and distal femur. Lateral and anteroposterior radiographs of the right stifle region revealed multiple exophytic masses arising from the femur, with mild bony reaction of the proximal tibia. Histologic examination of biopsy tissue revealed woven and lamellar bone with granulation tissue and skeletal muscle. Because the macaque was exhibiting no lameness or signs of pain, we decided to monitor the progression of the masses. Minimal change was noted during the time prior to study termination at 6.5 y of age. Necropsy revealed that the bony masses were cartilage-capped lesions arising near the growth plate of the distal femur and midshaft of the femur and tibia. Histologic examination revealed chondro-osseous exophytic growths that blended imperceptibly with the cortex and spongiosa of the femur, consistent with a final diagnosis of multiple osteochondromas.
Kristin A Matthews; Karen Strait; Fawn Connor-Stroud; Cynthia L Courtney
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Comparative medicine     Volume:  62     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-01     Completed Date:  2012-09-20     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-52     Citation Subset:  IM    
Department of Animal Resources, Yerkes National Primate Research Center, Atlanta, Georgia, USA.
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MeSH Terms
Animals, Laboratory
Autopsy / veterinary
Biopsy / veterinary
Femoral Neoplasms / veterinary*
Femur / pathology*,  radiography
Macaca mulatta*
Monkey Diseases / diagnosis*,  pathology
Osteochondromatosis / veterinary*
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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