Document Detail


Nonheritable cellular variability accelerates the evolutionary processes of cancer.
MedLine Citation:
PMID:  22509130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluctuations in cells and by physiological responses of cells to the environment. New approaches to drug design may be required to control nonheritable variability and the evolution of resistance to chemotherapy.
Authors:
Steven A Frank; Marsha Rich Rosner
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-04-03
Journal Detail:
Title:  PLoS biology     Volume:  10     ISSN:  1545-7885     ISO Abbreviation:  PLoS Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-17     Completed Date:  2012-08-07     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101183755     Medline TA:  PLoS Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1001296     Citation Subset:  IM    
Affiliation:
Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America. safrank@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology,  therapeutic use
Cell Transformation, Neoplastic*
Drug Resistance, Neoplasm
Homeostasis
Humans
Neoplasms / drug therapy,  pathology*
Phenotype
Grant Support
ID/Acronym/Agency:
GM087630/GM/NIGMS NIH HHS; U01-GM-76499/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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