| Nonheritable cellular variability accelerates the evolutionary processes of cancer. | |
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MedLine Citation:
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PMID: 22509130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises by stochastic fluctuations in cells and by physiological responses of cells to the environment. New approaches to drug design may be required to control nonheritable variability and the evolution of resistance to chemotherapy. |
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Authors:
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Steven A Frank; Marsha Rich Rosner |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-04-03 |
Journal Detail:
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Title: PLoS biology Volume: 10 ISSN: 1545-7885 ISO Abbreviation: PLoS Biol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-04-17 Completed Date: 2012-08-07 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101183755 Medline TA: PLoS Biol Country: United States |
Other Details:
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Languages: eng Pagination: e1001296 Citation Subset: IM |
Affiliation:
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Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America. safrank@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology,
therapeutic use Cell Transformation, Neoplastic* Drug Resistance, Neoplasm Homeostasis Humans Neoplasms / drug therapy, pathology* Phenotype |
| Grant Support | |
ID/Acronym/Agency:
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GM087630/GM/NIGMS NIH HHS; U01-GM-76499/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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