Document Detail

Nongenomic action of steroids in myometrial contractility.
MedLine Citation:
PMID:  11572328     Owner:  NLM     Status:  MEDLINE    
Steroid hormones are involved in several fundamental aspects of all living beings, with a few slight chemical differences among steroids being enough to give them the extraordinarily diverse biologic specificities that are important in animal physiology and medical therapeutics. Indeed, in the uterus, they have a remarkable action on uterine contractility with physiologic significance in the important reproductive processes of mammalian pregnancy and parturition. The regulation of progesterone on the myometrial contractile activity and related wider subjects of the endocrinology of pregnancy and parturition have been reviewed many times during the twentieth century. However, new data indicate that several progesterone metabolites and some synthetic steroids induce a progesterone-like uterine-relaxing effect. Experimental evidence from our laboratory has shown that 5-reduced progestins and androgens are more potent than progesterone itself in decreasing uterine contractility. The purpose of this review is to update current knowledge of endogenous and exogenous steroids on the phenomenon of uterine contractility, by summarizing their structural differences to induce changes on this process and discussing the possible mechanism of steroids to regulate uterine muscle activity.
M Perusqu?a
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Endocrine     Volume:  15     ISSN:  1355-008X     ISO Abbreviation:  Endocrine     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-09-26     Completed Date:  2002-02-13     Revised Date:  2010-06-24    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
Biomedical Research Institute, National Autonomous University of Mexico, Mexico City.
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MeSH Terms
Androgens / pharmacology
Hormones / pharmacology
Labor, Obstetric
Progesterone / metabolism,  pharmacology
Progestins / pharmacology
Steroids / pharmacology*
Uterine Contraction / drug effects*
Grant Support
Reg. No./Substance:
0/Androgens; 0/Hormones; 0/Progestins; 0/Steroids; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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