Document Detail

Nonfunctioning malignant paraganglioma of the posterior mediastinum with spinal cord compression. A case report.
MedLine Citation:
PMID:  8839476     Owner:  NLM     Status:  MEDLINE    
STUDY DESIGN: Case report and review of the literature. OBJECTIVE: To present a case with an uncommon nonfunctioning malignant paraganglioma of the posterior mediastinum with compression of the spinal cord. An update survey is given with respect to diagnostic, histopathologic, and therapeutic aspects of paragangliomas. SUMMARY OF BACKGROUND DATA: Paragangliomas in the posterior mediastinum are uncommon and rarely may produce spinal cord compression. To illustrate the low incidence, only two cases of paraganglioma of the posterior mediastinum were reported by the Mayo Clinic, Rochester, Minnesota, during a 40-year period. METHOD: Case report and review of the literature. RESULT: The diagnosis was made by modern imaging techniques (computed tomography, magnetic resonance imaging, and metaiodobenzylguanidine scan) and verified by computed tomography guided per thoracic puncture. A wide local resection was performed; the patient is disease-free 1 year after surgery. CONCLUSION: The uncertainty of prognosis and possibility of local recurrence of paragangliomas even after a long period emphasizes the importance of wide local surgical resection with or without adjuvant therapy and makes long-term follow-up and continued surveillance of the patient mandatory.
R J Noorda; P I Wuisman; A J Kummer; H A Winters; J A Rauwerda; S M Egeler-Peerdeman
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Spine     Volume:  21     ISSN:  0362-2436     ISO Abbreviation:  Spine     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-10     Completed Date:  1996-12-10     Revised Date:  2009-07-09    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1703-9     Citation Subset:  IM    
Department of Orthopaedic Surgery, Academic Hospital, Free University, Amsterdam, The Netherlands.
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MeSH Terms
Magnetic Resonance Imaging
Mediastinal Neoplasms / pathology*,  radiography,  therapy
Mediastinum / pathology*,  radiography,  surgery
Middle Aged
Paraganglioma / classification,  pathology*,  therapy
Radiography, Thoracic
Spinal Cord Compression / complications*,  pathology

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