Document Detail

Nonfunctional parathyroid carcinoma.
MedLine Citation:
PMID:  19967413     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Nonfunctional parathyroid carcinoma (PTC) is one of the rarest malignant diseases and only nine cases have been reported during the last 23 years. We present a case of nonfunctioning PTC and review the literature in an effort to provide a better understanding of this rare disorder. METHODS: One patient with nonfunctioning PTC was presented, detailing the clinical features, histologic findings, diagnosis, and treatment. Together with data from the other nine cases reported last 23 years, the related literature is also reviewed. RESULTS: The presented case was a 47-year-old man with a 2-month history of an enlarging painless cervical mass followed by a 2-week history of hoarseness. Clinical and laboratory evaluations failed to reveal evidence of hyperparathyroidism. Pathological analysis of the resected tumor disclosed findings consistent with PTC. The nonsecretory state of the tumor was further supported by immunoreactivity for parathyroid hormone in tissue, and normal serum levels of this peptide and calcium preoperatively and postoperatively. CONCLUSION: Most nonfunctional PTC is detected late due to a paucity of symptoms, of which a palpable neck mass is the most common. Patients with nonfunctioning PTC appear to have a poorer prognosis than do those with functioning parathyroid cancers.
Wen Chao Gao; Can Ping Ruan; Jun Chu Zhang; Hui Min Liu; Xin Yun Xu; Yan Ping Sun; Qiang Wang
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-12-05
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  136     ISSN:  1432-1335     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  969-74     Citation Subset:  IM    
Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, 415 Feng Yang Road, 200003 Shanghai, People's Republic of China.
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MeSH Terms
Middle Aged
Parathyroid Neoplasms / diagnosis*,  surgery*

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