Document Detail


Nonfatal pulmonary Trichoderma viride infection in an adult patient with acute myeloid leukemia: report of one case and review of the literature.
MedLine Citation:
PMID:  15994049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trichoderma species have been recognized to be pathogenic in immunosuppressed hosts with increasing frequency. Trichoderma species are responsible for continuous ambulatory peritoneal dialysis associated peritonitis and infections in immunocompromised patients with a hematologic malignancy or solid organ transplantation. Trichoderma longibrachiatum is the most common species involved in these infections. We report the first case of nonfatal pulmonary infection caused by Trichoderma viride in leukemia patient. It had a successful answer to new antifungal agents as voriconazole and caspofungin. Trichoderma viride was isolated from pulmonary aspirate culture from a 54-year-old female who had received chemotherapy for acute myeloid leukemia. The minimal inhibitory concentrations for the organism were the following: amphotericin B (0.25 microg/mL) and voriconazole (2 microg/mL). Initially, she was treated unsuccessful with liposomal amphotericin B and voriconazole and caspofungin were added later. The patient is alive. We report one case along review of the literature.
Authors:
Dunia De Miguel; Peña Gómez; Rosa González; Julio García-Suárez; Juan Antonio Cuadros; Maria Helena Bañas; Juan Romanyk; Carmen Burgaleta
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  53     ISSN:  0732-8893     ISO Abbreviation:  Diagn. Microbiol. Infect. Dis.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-26     Completed Date:  2006-02-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
Affiliation:
Servicio de Hematología, Hospital Universitario Príncipe de Asturias, 28805 Alcalá de Henares, Madrid, Spain. duniamll@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antifungal Agents / pharmacology*,  therapeutic use
Female
Humans
Leukemia, Myeloid, Acute / complications*
Lung Diseases / microbiology
Middle Aged
Mycoses / etiology*,  microbiology*
Opportunistic Infections / etiology,  microbiology
Trichoderma / drug effects,  isolation & purification*,  pathogenicity
Chemical
Reg. No./Substance:
0/Antifungal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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